Fidia Advanced Biopolymers S.r.l.

Fidia Farmaceutici S.p.a.

Eurand International S.p.a.

Fidia Advanced Biopolymer S.r.l.

Paolo Pallado

Lanfranco Callegaro

Luca Benedetti

Maurizio Dalle Carbonare

Marco Baggio

Italo Colombo

Biocompatible and biodegradable, three-dimensional structures containing hyaluronic acid derivatives, obtained by the technique of precipitation induced by supercritical antisolvent (SAS), can be used in the field of medicine and surgery.

Three-dimensional structures containing hyaluronic acid derivatives obtained by the supercritical antisolvent technique

The following description refers to a process for the impregnation of cross-linked polymers with an active ingredient. The process is based on the used of compressed fluids, in particular CO, with antisolvent effect, and involves the steps of impregnating the polymer with an active ingredient solution, adding a compressed fluid until precipitation of the active ingredient caused by the compressed fluid antisolvent effect, removing the solvent and the compressed fluid. The process allows to obtain accelerated release pharmaceutical formulations that, compared with the formulations already known, contain larger quantities of amorphous or nanocrystalline active ingredient.

Process for the preparation of accelerated release formulations using compressed fluids

Crosslinked compounds of hyaluronic acid and the derivatives thereof, prepared by the technique of precipitation induced by supercritical antisolvent (SAS), can be used to advantage for the preparation of biomaterials for use in the field of medicine and surgery and in tissue engineering for medical and surgical purposes.

Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique

Microspheres, having a size lower than 1&mgr; and comprising a biocompatible polysaccharidic polymer, are prepared with a process comprising the precipitation of polymer induced by means of a supercritical antisolvent (SAS). These microspheres are used as vehicling agents or carriers in the preparation of pharmaceutical compositions administrable by oral, nasal, pulmonary, vaginal or rectal route. These microspheres can also be advantageously used as vehicling agent or carriers in the preparation of pharmaceutical compositions for the treatment of human diseases associated with genic defects, for the preparation of diagnostics and in the agro-alimentary industry.

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Abano Terme, Italy

Paolo Pallado