Simes Societa Italiana Medicinali E Sintetici S.p.a.

Simes S.p.a.

Paolo Ghirardi

Cesare Casagrande

Giorgio Ferrari

Leon I Goldberg

Theophile Godfraind

Germano Marchetti

Pharmaceutical compositions which contain epinine or a pharmaceutically acceptable salt thereof, and allow to reach a release of epinine comprised between 0.5 and 5 .mu.g/Kg/minute. Said compositions are useful in treating congestive heart failures; they stimulate the heart contractility, show a vasodilating and bronchodilating activity as well as a vasodilating activity on specific districts and particularly on the renal district without causing vasoconstrictive and pressor effects.

Epinine and the therapeutic use thereof

The magnesium salt of creatinol-O-phosphate, having the formula: ##STR1## is useful in the treatment and in the prevention of the myocardiac infarction. The preparation of the above magnesium salt takes place by reacting creatinol-O-phosphate, as a water solution, with a reactive magnesium compound. The magnesium salt according to the invention may be obtained in either anhydrous or hydrated form and is useful for the preparation of the normal pharmaceutical formulations for the administration by oral and parenteral route.

Creatinol-O-phosphates having therapeutical action

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Milan, Italy

Paolo Ghirardi