Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Other

Paolo DeWitt

Maria Ornella Tinti

Carlo A Bagolini

Emma Quaresima

Enrico Diamanti

Maria T Ramacci

A novel class of mercapto acyl-carnitines is disclosed, wherein the mercapto acyl radical is the radical of saturated mercapto acids having from 2 to 10 carbon atoms. These mercapto acyl-carnitines are prepared, e.g., by first preparing the corresponding halogen acyl-carnitine and then substituting therein, by nucleophylic substitution, the --SH group for the halogen atom. These mercapto acyl-carnitines are useful therapeutic agents, e.g., for the treatment of intoxications and burns and as mucolytic agents. Dithio diacyl carnitines and hydrochloride salts thereof, which are intermediates, are also disclosed.

Mercapto acyl-carnitines and pharmaceutical compositions containing same

A novel class of esters of mercapto acyl-carnitines is disclosed, wherein the mercapto acyl radical is the radical of saturated mercapto acids having from 2 to 10 carbon atoms. These esters of mercapto acyl-carnitines are prepared e.g. by first preparing the corresponding ester of halogen acyl-carnitine and then substituting therein, by nucleophylic substitution, the --SH group for the halogen atom. These esters of mercapto acyl-carnitines are useful therapeutic agents, e.g. for the treatment of intoxications and burns, and as mucolytic agents.

Esters of mercapto acyl-carnitines and pharmaceutical compositions

A process for manufacturing the D camphorate of L carnitinamide and the D camphorate of D carnitinamide is disclosed, wherein D,L carnitinamide hydrochloride is converted to D,L carnitinamide free base which directly reacts with D camphoric acid either as an aqueous suspension or in solid form, thus obtaining a solution of D camphorate of D,L carnitinamide. The resolution of the optical isomers is achieved by drying this solution and taking up the residue with isopropanol, whereupon the D camphorate of L carnitinamdide crystallizes out of the isopropanol solution and the D camphorate of D carnitinamide remains in solution.

Process for manufacturing D camphorate of L carnitinamide and D

Process for the production of aromatic alcohol and aldehydes comprising three steps, the first one consisting of reacting an aromatic acid with ethyl or isobutyl chloroformiate to obtain the corresponding mixed anhydride, the second one consisting of the hydrogenation of the mixed anhydride to obtain the corresponding benzyl alcohol, and the third one consisting of the oxidation of the alcohol to the corresponding aldehyde.

Process for preparing aromatic aldehydes and alcohols

N-6-chloronicotinoyl-d,l-homocysteine thiolactone of the formula ##STR1## and method for its preparation are described. The compound has antilipolytic activity and is useful in compositions for treatment of conditions of elevated free fatty acid and triglyceride plasma levels.

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Rome, Italy

Paolo DeWitt