Zambon Group S.p.a.

Epta S.p.a.

Zambon Group

Paolo Cavalleri

Francesco Santangelo

Stefania Montanari

Francesco Marchini

Cristina Fraire

Daniele Mazzola

Mario De Bona

Claudio Giordano

Marco Villa

Mauro Napoletano

Maurizio Paiocchi

Claudio Semeraro

Giancarlo Grancini

Gian Carlo Grancini

Lorenzo Pradella

Napoletano Mauro

Felice Pocchiari

Claudio Masotto

Davide Bortoluzzi

A vapor compression refrigeration system has a main refrigerant circuit having a primary compressor group, a gas cooler or condenser, an expansion device, a liquid receiver, and at least one evaporator. An emergency circulation duct fluidically connects the liquid receiver to the main circuit to allow a flow of refrigerant from the liquid receiver to the gas cooler. An emergency compressor group in the emergency circulation duct is activatable when pressure inside the liquid receiver or in the duct upstream of the emergency compressor group meets or exceeds a predefined emergency pressure threshold. An uninterruptible power supply powers the emergency compressor group and expansion device during a shutdown of the refrigeration system. When pressure inside the liquid receiver or in the duct upstream of the emergency compressor group equals or exceeds the predefined emergency pressure threshold, an emergency circulation of refrigerant fluid is activated through the emergency circulation duct.

Vapor compression refrigeration system capable of operating in transcritical mode and method of operating such a system

A refrigeration plant with multiple evaporation levels, operating according to a vapour compression cycle and including a circuit having a high-pressure branch HP, wherein is arranged at least one heat exchanger, and two or more low-pressure branches, each of which operates at a different evaporation level to serve users having different refrigeration requirements. In each of the low-pressure branches the plant comprises an expansion device, at least one evaporator and a compressor group. At least one evaporator of each low-pressure branch is connected directly to the high-pressure branch. At least a first low-pressure branch comprises a liquid separator fluidically connected: to the evaporator outlet to collect the liquid exiting the evaporator when operating in overfeeding conditions; and to the intake of the compressor group. Such liquid separator is fluidically connected to a second low-pressure branch upstream of the expansion device of such second low-pressure branch through a first connection duct.

Refrigeration plant with multiple evaporation levels and method of managing such a plant

Hydroxymethyl derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene as cardiovascular agent

Naphthothiazolone derivatives active on the D.sub.3 dopaminergic receptor

Compounds of the formula: ##STR1## wherein the variables are as defined in the specification. These compounds are useful in the treatment of arterial hypertension and heart failure, of renal insufficiency, of peripheral arteriopathies and of cerebrovascular insufficiencies.

Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the

5-hydroxymethyl-2-aminotetralins as cardiovascular agents

Compounds of formula ##STR1## wherein R, R', R', R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X, Y, m, n and p have the meanings reported in the description; and their pharmaceutically acceptable salts are described. The compounds of formula I are useful in the treatment of arterial hypertension and congestive heart failure, of renal failure, of peripheral arteriopathies, of cerebrovascular insufficiencies and of ischemic cardiopathy.

A process for the direct and regioselective functionalization of phenothiazine which allows one to introduce an SH group in position 2, said process comprising the sulfination or sulfonation of the phenothiazine N-protected with an alkoxycarbonyl, an alkylsulfonyl or an arylsulfonyl group, the reduction of the produce obtained to give the N-protected 2-mercapto-phenothiazine, and the deprotection of the nitrogen atom. The thus-obtained 2-mercapto-phenothiazine is an important intermediate for the preparation of pharmacological active compounds.

Process for the direct and regioselective functionalization in position

A process for the selective dehalogenation in position 5 of the naphthalenic nucleus of compounds of formula ##STR1## (wherein X, X.sub.1 and R have the meanings reported in the description) by treatment with a dehalogenating agent selected among hydrogen sulfide, aliphatic thiols or mixtures thereof in an inert anhydrous solvent at acid pH.

Process for the dehalogenation of naphthalene derivatives

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Milan, Italy

Paolo Cavalleri