Institut Pasteur

Centre National De La Recherche Scientifique

Institute Pasteur

Instituto Gulbenkian De Ciencia

Instituto De Ciencias Abel Salazar

Paola Minoprio

Wim Degrave

Armand Berneman

Catherine Rougeot

Pedro Alzari

Mario Arala-Chaves

Antonio Coutinho

Alain Cosson

Bernardo Reina San Martin

Nathalie Chamond

Alejandro Buschiazzo

Sara Isabel Mansinho Fernandes De Almeida, Legal Representative

Christophe Gregoire

Christophe Grégoire

Wim DeGrave

Arnaud Blondel

Eduarda Maria Santos Dores Arala-Chaves

Christophe Inst Gulbenkian De Ciencia Gregoire

The present invention provides the crystal structure of thePRACA proline racemase. Methods of modelling drugs that treat or prevent infection byare also provided, as are the drugs that are identified.

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A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen, such as a eukaryotic amino acid racemase, in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.

Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens

Crystallographic structure of TcPRACA and uses therefor

This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs and more specifically SEQ ID NOS: 1-4. This invention also relates to antibodies specific for the peptides and to immune complexes of these antibodies with the peptides. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.

Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase

A method of preventing or inhibiting infection by a parasite or virus in vivo comprises administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.

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Villiers sur Marne, France

Paola Minoprio