Eniricerche S.p.a.

Paola Cosmina

Guido Grandi

Paolo Carrera

Giuliano Galli

Francesca De Ferra

Gianni Frascotti

Elisabetta Franchi

Marina Del Bue

The invention relates to a new asporogenous strain of,which has been deposited at the Centraalbureau Voor Schimmelcultures under the number CBS 432.90. This strain, which shows a frequency of reversion to the formation of spores of less than about 10,and good plasmid stability, is suitable as a host in a host-vector system for the preparation of heterologous products of interest.

Asporogenous strain of bacillus subtilis and its use as a host for the preparation of heterologous products

Disclosed is a novel method for the in vivo and in vitro synthesis of modified peptides, using either engineered microorganisms capable of expressing peptide synthetases with modified substrate specificity, or peptide synthetases extracted from said microorganisms.

Method for genetically manipulating peptide synthetases

The description relates to a plasmid vector expression in Bacillus and used for cloning the structural gene which codes for the human growth hormone, a recombinant DNA molecule comprising plasmid vector and the structural gene of the human growth hormone and a method of preparing the hormone comprising inserting the recombinant DNA molecule into strains of Bacillus and cultivating the resulting transformed strains in a suitable culture environment and recovering the thus-synthesized hormone from the cells.

Plasmid vector for expression in bacillus and used for cloning the

The present invention relates to a stable mutant of Bacillus subtilis which can produce surfactin with high yields, a method of producing surfactin with the use of the strain and the use of the surfactin obtained for pharmaceutical, energy and environmental problems.

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Milan, Italy

Paola Cosmina