Nektar Therapeutics

Nektar Therapeutics Al, Corporation

Paola Caliceti

J Milton Harris

Francesco Maria Veronese

Oddone Schiavon

Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polyand poly, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGand mPEGhave the structure CHO&#x2014;(CHCHO)CHCH&#x2014; wherein n may be the same or different for poly- and poly- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.

Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules

Growing community of inventors

Padua, Italy

Paola Caliceti