Harvard College

Pao-Tien Chuang

Andrew P McMahon

The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as 'hedgehog interacting proteins' or 'HIPs', which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.

Hedgehog interacting proteins and uses related thereto

The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as 'hedgehog interacting proteins' or 'HIPs', which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.

The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as &ldquo;hedgehog interacting proteins&rdquo; or &ldquo;HIPs&rdquo;, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.

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Cambridge, MA, United States of America

Pao-Tien Chuang