Jacobio Pharmaceuticals Co., Ltd.

Panliang Gao

Cunbo Ma

Di Kang

Huifeng Han

Xinping Wu

Shaojing Hu

Jinlong Bai

Chunwei Wen

Xiaoyan Pei

Zilong Xu

Jie Chu

This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

Heterocyclic derivatives useful as SHP2 inhibitors

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder. 

Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder. 

Heterocyclic ring derivatives useful as SHP2 inhibitors

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Panliang Gao