Haisco Pharmaceuticals Pte. Ltd.

Sichuan Haisco Pharmaceutical Co., Ltd.

Haisco Chengdu Pharmaceutical Technology Co., Ltd.

Haisco Innovative Pharmaceutical Pte. Ltd.

Pangke Yan

Chen Zhang

Fei Ye

Yao Li

Pingming Tang

Lei Chen

Bo Xu

Jianmin Wang

Xin Liu

Zongjun Shi

Wenjing Wang

Jia Ni

Guobiao Zhang

Xiaobo Zhang

Dengyu Zheng

Yajun Wang

Zhenggang Huang

Yan Yu

Yonggang Wei

Feng Peng

Wei Zheng

Hua Mao

Yi Mo

Fangqiong Li

Linlin Qin

Honghu Li

Jianyu Liu

Anbang Huang

Fujun Cheng

Ziwei Zhao

Xuanmiao Zhang

Juanjuan Deng

Longbin Huang

Yuting Liao

Hong Mu

Guozhi Zhu

Xiaogang Chen

Yuquan Zhang

Shoutao Wu

Qingyang Yu

Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof

The present disclosure provides a pharmaceutical composition of fused tricyclic gamma-amino acid derivatives and the use thereof. The pharmaceutical composition includes: (i) a compound having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, as an active material, in an amount of 1% to 45% by weight; (ii) optionally one or more fillers in an amount of 50% to 95% by weight; (iii) optionally one or more lubricating agents in an amount of 0.1% to 5.5% by weight; and the sum of weight percentages of the all components is 100%, wherein the pharmaceutically acceptable salt of the compound of formula (I) has a structure as follows:

Composition of fused tricyclic gamma-amino acid derivatives and the preparation thereof

Substituted piperidines as BTK inhibitors, a preparation method thereof and a pharmaceutical application thereof. The substituted piperidines is a compound represented by a general formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, and the substituted piperidines is used to treat BTK-related diseases such as tumors or autoimmune system diseases.B-L-K&#x2003;&#x2003;formula (I)

Substituted piperidines as BTK inhibitors

The invention provides a peptide amide compound represented by the general general formula (I), a preparation method thereof, and a medical application thereof. The compound has a novel structure, better biological activity, and better analgesic effect. 

Peptide amide compound and preparation method and medical use thereof

The present disclosure provides a pharmaceutical preparation of a compound of formula (I) or a stereoisomer, pharmaceutically acceptable salt, or prodrug thereof. The present disclosure further provides a method for general anesthesia or sedation for mammals. Also provided are kits and manufactured products of the medicament and the pharmaceutical composition and a method for using the medicament and the pharmaceutical composition. 

Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament

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Chengdu, China

Pangke Yan