American Cyanamid Company

Other

Panayota Bitha

Yang-I Lin

Joseph J Hlavka

Ralph G Child

Carl B Ziegler

Gregg Brian Feigelson

Karen Bush

Timothy W Strohmeyer

Subas Sakya

Gerardo De Francisco

Zhong Li

Yang I Lin

3,6-disubstituted penam sulfone derivatives

Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.

(Gem-heterocyclodimethanamine-n,n&prime;)platinum complexes

Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri-substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.

2-thiosubstituted carbapenems

Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, method of inhibiting a Beta-lactamase enzyme by administering said compounds, processes for preparing the compounds and new intermediates useful in the process are disclosed.

Method of inhibiting a .beta.-lactamase enzyme by administering novel

Tetrahydrofuanyl compounds of the following formulae: ##STR1## are disclosed.

Method for producing tetrahydrofuranyl compounds

Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.

This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.

Synthesis of cisplatin analogs

Novel antibacterial compounds of the formula: ##STR1## in which R.sub.1 is alkyl (C.sub.1 -C.sub.4), cycloalkyl (C.sub.3 -C.sub.6), alkoxy (C.sub.1 -C.sub.4), alkylamino (C.sub.1 -C.sub.3), vinyl, phenyl, benzyl, --CH.sub.2 CH.sub.2 F or mono or polysubstituted phenyl (wherein the substituent is halogen, CF.sub.3 or OCH.sub.2 F); n is an integer of from 1 to 4; and R.sub.2 is cis or trans hydroxy, amino, mono or disubstituted alkyl (C.sub.1 -C.sub.3) amino and the pharmacologically accepted salts thereof are described.

7-(substituted)cycloalkylamino-1

Organic-platinum complexes useful as anti-cancer agents in the treatment of tumors sensitive to the subject compounds are described.

(2,2-bis(aminomethyl)-1,3-propranediol-N,N')platinum complexes

(Gem-heterocyclodimethanamine-N,N')platinum complexes

This disclosure describes water soluble platinum complexes of novel malonate derivatives which possess the property of inhibiting the growth of tumors in mammals.

Water soluble platinum complexes of novel malonate derivatives

Novel organic compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## and &gt;NR.sub.3 where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and methods of using the compounds to treat tumors in mammals.

Platinum complexes of amines with novel dibasic acids

This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quin oli necarboxylic acid antibacterial agents.

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Pomona, NY, United States of America

Panayota Bitha