Biopharma Works LLC

Becton Dickinson and Company Limited

Krouzon Pharmaccuticals, Inc.

Panayiotis Zagouras

Robert A Volkmann

Anthony Marfat

Anton Franz Joseph Fliri

Peter Cornelius

Frederick Nelson

Tobin J Hellyer

Ray A McMillian

Christing A Rostkowski

Fredrick Raymond Nelson

The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Octahydrocyclopenta[c]pyrrole allosteric inhibitors of SHP2

The aspects of the disclosed embodiments are directed to novel compounds, specifically, quaternary ammonium derivatives of tertiary amine containing opioid drug compounds such as hydrocodone, hydromorphone and oxycodone, formulations containing said. compounds or pharmaceutically acceptable salts thereof, which are capable of providing controlled release of the opioid drug upon administration to a patient in order to treat pain.

Compounds for treatment of pain

The invention is directed to novel compounds, formulations containing said compounds or pharmaceutically acceptable salts thereof which are suitable for administration to a patient.

Amplification primers and methods for specific amplification and detection of a Salmonella spp. target are disclosed. The primer-target binding sequences are useful for amplification and detection of Salmonella target in a variety of amplification and detection reactions.

Amplification and detection of Salmonella spp

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Old Saybrook, CT, United States of America

Panayiotis Zagouras