Hoffmann-La Roche Inc.

Panayiotis Kalaritis

David L Coffen

John Joseph Partridge

John J Patridge

Herbert R Brinkman

John F Morrissey

A process for preparing N4-acyl-5'-deoxy-5-fluorocytidine derivatives of formula III: ##STR1## by selective deacylation, wherein R is alkyl, cycloalkyl, alkenyl, aralkyl or aryl, which comprises reacting a compound of formula II, ##STR2## wherein R is as defined above, with a base in an aqueous or inert organic solvent.

Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives

Enantiomerically pure (2R)-2-hydroxy arylalkanoic acid esters and (2S)-2-hydroxy arylalkanoic acids are prepared by the Pseudomonas lipase-catalyzed selective hydrolyxis of racemic (2RS)-2-hydroxy arylalkanoic acid esters in solution or suspension in an aqueous medium at a controlled pH of from about 5 to about 9.

Production of 2-hydroxy substituted arylalkanoic acids and esters by

Enantiomerically pure (2R)-hydroxy-substituted benzopyran-2-carboxylic acid esters and (2S)-hydroxy-substituted benzopyran-2-carboxylic acids, are prepared by the Pseudomonas lipase-catalyzed selective hydrolysis of racemic (2RS)-hydroxy-substituted benzopyran-2-carboxylic acid esters in solution or suspension in an aqueous or aqueous/organic medium, at a pH of from about 5 to about 10.

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New Providence, NJ, United States of America

Panayiotis Kalaritis