Firmenich Sa

Adlai Nortye Biopharma Co., Ltd.

Pan Li

Qi Rong Wang

Michel Schalk

Qi Wang

Ji Wang

Yang Lu

Olivier Haefliger

Xiu-Feng He

Qiaodong Wen

Fabienne Deguerry

Zhiyong Yu

Yu Zhou

Yufeng Chen

Donghui Yang

Zhiying Huang

Quan Gan

Zong-Xia Yu

Xiufeng He

Eric Wen-Bo Liu

Enguang Feng

Beidi Xu

Canfeng Liu

Kaixuan Chen

Qingchong Qiu

The present invention provides compounds of Formula (I) or (II), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) or (II) to prevent and/or treat immune-related disorders.

Highly active sting protein agonist compound

Provided is a compound represented by formula (I) and a pharmaceutical composition thereof, as well as a method for using a compound represented by formula (I) to prevent and/or treat immune-related disorders.

PD-L1 antagonist compound

The present application relates to a method of producing drimenol and/or drimenol derivatives by comprising contacting at least one polypeptide with farnesyl diphosphate (FPP). The method may be performed in vitro or in vivo. Also provided are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. The method further provides host cells or organisms genetically modified to express the polypeptides and useful to produce drimenol and/or derivatives of drimenol.

Sesquiterpene synthases for production of drimenol and mixtures thereof

Described herein is a method of producing drimenol and/or drimenol derivatives, the method including contacting at least one polypeptide with farnesyl diphosphate (FPP). The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. Also described herein are host cells or organisms genetically modified to express the polypeptides and useful to produce drimenol and/or derivatives of drimenol.

The present invention relates to a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, a method for inhibiting indoleamine 2,3-dioxygenase, and its use in medicine. 

Indoleamine 2,3-dioxygenase inhibitors and use of same in medicine

The present invention discloses a method of producing drimenol and/or drimenol derivatives by contacting a polypeptide with farnesyl pyrophosphate. Also provided is an amino acid sequence of a polypeptide useful in the methods of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.

Drimenol synthases III

Provided herein is an isolated polypeptide from'Beverleyensis' orcomprising a (+)-cedrol or a (&#x2212;)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from'Beverleyensis' orencoding a (+)-cedrol or (&#x2212;)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (&#x2212;)-thujopsene.

Production of fragrant compounds

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Hangzhou, China

Pan Li