Elan Pharmaceuticals, Inc.

Athena Neurosciences, Inc.

Pamela S Keim

Sukanto Sinha

John P Anderson

Lisa Clair McConlogue

Hua Tan

Susanna M S Chrysler

Theodore A Yednock

Susanna M Chrysler

Compositions comprising a novel protease capable of cleaving &#x3b2;-amyloid precursor protein (APP) on the amino-terminal side of the &#x3b2;-amyloid peptide therein are provided. The protease is designated &#x3b2;-secretase. Reaction systems comprising &#x3b2;-secretase may be used in screening assays to monitor &#x3b2;-secretase modulated cleavage of APP and to identify &#x3b2;-secretase inhibitors, wherein the &#x3b2;-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of &#x3b2;-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.

Methods and compositions for inhibiting &#x3b2;-secretase

Compositions comprising a novel protease capable of cleaving &bgr;-amyloid precursor protein (APP) on the amino-terminal side of the &bgr;-amyloid peptide therein are provided. The protease is designated &bgr;-secretase. Reaction systems comprising &bgr;-secretase may be used in screening assays to monitor &bgr;-secretase modulated cleavage of APP and to identify &bgr;-secretase inhibitors, wherein the &bgr;-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of &bgr;-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.

&bgr;-secretase antibody

The invention relates to protein or polypeptide compositions capable of inhibiting leukocyte adhesion to, and transmigration across endothelial tissue. The invention further relates to nucleic acid molecules encoding such peptides, pharmaceutical compositions containing such peptides and methods of using such polypeptides.

Integrin blocking molecule

Compositions comprising a novel protease capable of cleaving .beta.-amyloid precursor protein on the amino-terminal side of the .beta.-amyloid peptide therein are provided. The protease is designated .beta.-secretase. The .beta.-secretase may be used in screening assays to identify .beta.-secretase inhibitors, or the .beta.-secretase is combined with a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance.

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San Mateo, CA, United States of America

Pamela S Keim