Eli Lilly and Company

Other

Pamela Jean Mitchell

Andrew Ihor Korytko

Rosamund Carol Smith

Rong Wang

Julian Davies

Bryan Edward Jones

Linda Maureen O'Bryan

Linda O'Bryan (Nee Tobias)

Bomie Han

Joan L Boucher

Linda O O'Bryan

Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bond density, or for the treatment of various disorders in mammalian and avian species, X17251.

Anti-myostatin antibodies

A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing hone density, or for the treatment of various disorders in mammalian and avian species.

A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.

Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.

A handle cover for a shopping cart is formed from a padded fabric strip. VELCRO fasteners are provided for securing the strip around the handle of a conventional shopping cart. The cover provides protection against germs, dirt and disease to small children riding in the shopping cart child seat. Various toys for the amusement of the child may be secured to the fabric cover. A seat cover for providing added protection and comfort to a child riding in a shopping cart seat includes strap fasteners for attachment to the handle cover. The seat cover and handle cover may be folded to compact sizes for convenient storage and transportation.

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Indianapolis, IN, United States of America

Pamela Jean Mitchell