National Institutes of Health, a Component of the US Dept. of Health & Human Services

US Government As Represented by the Secretary of the Army

The United States of America As Represented by the Secretary of

Rutgers, the State University of New Jersey

Dartmouth College

Hadasit Medical Research Services and Development Ltd.

Shirvan, Mitchell

Pamela Gehron Robey

Stan Gronthos

Songtao Shi

Masako Miura

Sergei Kuznetsov

Gordon W Gribble

Michael B Sporn

Raphael Gorodetsky

Karen T Liby

Nanjoo Suh

Mitchell Shirvan

Marian F Young

Larry W Fisher

Damian Medici

Paolo Bianco

David Rowe

Paul Krebsbach

Mahesh H Mankani

John D Termine

Joseph Featherall

Astar Hailu-Lazmi

Methods are provided for promoting cartilage growth and/or repair. The methods include, administering locally to a site in a subject in need thereof, bone marrow stromal cells attached to fibrin microbeads comprising crosslinked hyaluronic acid and thereby producing stable cartilage locally at the site in the subject.

Formation of stable cartilage

The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.

Postnatal stem cells and uses thereof

The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.

Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions

The present invention provides a culture of isolated adult human dental pulp stem cells that can differentiate into dentin/pulp tissue that can be used to produce a tooth in a human being. The present invention further provides a method of regenerating human dentin/pulp tissue.

Adult human dental pulp stem cells in vitro and in vivo

An in vivo model for human bone metabolism. Human marrow stromal fibroblasts are isolated, expanded in culture, combined with ceramic powder (hydroxyapatite) delivery vehicles with or without fibrin glue and implanted into a mammal. This protocol results in the formation of self-maintained human bone which supports hematopoiesis. This model system can be used to screen compounds which inhibit or stimulate bone formation. The marrow stromal fibroblast delivery vehicles can be implanted into humans to augment bone implants or to repair bone defects.

Formation of human bone in vivo using ceramic powder and human marrow

Amino acid and cDNA sequences of a plurality of human bone matrix proteins and their uses have been described.

CDNA sequences of human bone matrix proteins

Growing community of inventors

Bethesda, MD, United States of America

Pamela Gehron Robey