S.p.i. Synthetic Peptides Incorporated

University Technologies International, Inc.

Pamela A Sokol

Robert S Hodges

Randall Thomas Irvin

William Paranchych

Donald E Woods

Cora D Kooi

The present invention provides immunogenic compositions comprising peptides derived from the amino acid sequence of,for protecting susceptible hosts against diseases caused by bacterial pathogens which secrete a zinc metalloprotease.

Conserved metalloprotease epitopes

The invention described includes methods and compositions useful in preventing infection by Pseudomonas aeruginosa and related organisms. Diclosed is a peptide having the sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseudomonas aeruginosa pilin protein. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against Pseudomonas aeruginosa as well as against such cross-reactive microorganisms.

Method of prevention of pseudomonas infection

A peptide having a sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseusdomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms.

Growing community of inventors

Calgary, Canada

Pamela A Sokol