Abbott Cardiovascular Systems, Inc.

Advanced Cardiovascular, Inc.

Pamela A Kramer-Brown

David C Gale

John Arthur Simpson

Paul M Consigny

Fozan El-Nounou

Florian Ludwig

Puneet Kamal Singh Gill

Austin M Leach

John William Morris, Jr

Stephen D Pacetti

Randolf Von Oepen

Travis Richard Yribarren

William E Webler, Jr

Kayla L Calvert

Yunbing Wang

Li Fu Chen

John Joseph Stankus

Shubhayu Basu

Daniel L Cox

Keif M Fitzgerald

John Francis Boylan

Klaus Kleine

Boris Anukhin

Jesus Magana

Vincent J Gueriguian

Barbara E Stamberg

Rainer Bregulla

David A Mackiewicz

Florian Niklas Ludwig

Karim Said Osman

Larry G Baughman

Yuet Mei Khong

Neil Burkhart

Randolpf Von Oepen

Duane M DeMorre

Gregory W Johnson

Z C Lin

A stent comprising a cobalt-based alloy comprising 18-50 weight % cobalt (Co), 10-25 weight % chromium (Cr), 10-15 weight % tungsten (W), 0-2 weight % of manganese (Mn), 0-3 weight % iron (Fe), and 10-65 weight % metal member selected from a platinum group metal.

Radiopaque intraluminal stents

A stent having a cobalt-based alloy, wherein the cobalt-based alloy is free of nickel (Ni), the cobalt-based alloy including 10-65 weight % metal member selected from a platinum group metal, a refractory metal, or combinations thereof, 15-25 weight % chromium (Cr), 4-7 weight % molybdenum (Mo), 0-18 weight % iron (Fe), and 22-40 weight % cobalt (Co).

Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium, tungsten, and nickel. Tungsten is present above its solubility limit (about 15%), but is still only present as a super-saturated, primarily single-phase material exhibiting an FCC microcrystalline structure.

Radiopaque intraluminal stents comprising cobalt-based alloys with primarily single-phase supersaturated tungsten content

Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, precious metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Refractory metals include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, and precious metals include silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute at least partially for nickel, such that the alloy exhibits reduced nickel content, or is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.

Radiopaque intraluminal stents comprising cobalt-based alloys containing one or more platinum group metals, refractory metals, or combinations thereof

Various embodiments of stents with a polymeric body with radiopaque metallic particles incorporated in the stent body.

Composite polymeric and metallic stent with radiopacity

Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices.

Method and apparatus for delivering an agent to a kidney

A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.

Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.

Apparatus and methods for supporting cardiac ischemic tissue

The present disclosure is directed to tantalum-alloy products, implantable medical devices that incorporate tantalum-alloy products such as stents or other implantable medical devices, methods of making and/or processing the tantalum-alloy products and implantable medical devices, and methods of using the implantable medical devices. In an embodiment, a stent includes a stent body having a plurality of struts. At least a portion of the stent body is made from a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % ('wt %') to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof, such as yield strength, ultimate tensile strength, or ductility.

Heat-treated tantalum-alloy products, implantable medical devices incorporating same, and methods of processing tantalum-alloy products

Methods for making devices include providing a tubular member to be formed into a device, placing a removable sacrificial block material in the lumen of the tubular member and laser cutting the tubular member. A tubular member made from nickel-titanium alloy can be tightly adhered to a sacrificial sleeve utilizing the phase changes associated with nickel-titanium. A mandrel which includes an enlarged diameter section causes the workpiece to expand slightly within its elastic deformation range to dislodge islands from the workpiece. Such a mandrel could be formed from a tubular member which has a central lumen that can be used to deliver a pressurized medium to 'blast' islands from the workpiece.

Methods for laser cutting tubing to make medical devices

Medical devices are manufactured from fine grained materials, processed from of a variety of metals and alloys, such as stainless steel, cobalt-chromium and nickel-titanium alloys. A fine grained metal or alloy is formed from a specimen rapidly heated to its recrystallization temperature, and then subjected to high temperature, multi-axial deformation, for example, by heavy cross-forging or swaging. The deformed specimen may be cooled and reheated to a second recrystallization temperature. The metal or alloy in the specimen is then allowed to recrystallize, such that the grain size is controlled by quenching the specimen to room temperature. A desired medical device is then configured from the fine grained material. Decreasing the average grain size of a substrate material and increasing the number of grains across a thickness of a strut or similar component of the medical device increases the strength of the device and imparts other beneficial properties into the device.

Manufacture of fine-grained material for use in medical devices

Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.

Implantable medical devices for local and regional treatment

Growing community of inventors

San Jose, CA, United States of America

Pamela A Kramer-Brown