Yale University

Pamela A Havre

Peter M Glazer

Graeme L Hammond

A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formation of the triplex, the mutagen is brought into proximity with the target molecule and causes a mutation at a specific site therein. The mutation activates, inactivates or alters the activity and function of the target molecule.

Chemically modified oligonucleotide for site-directed mutagenesis

A peptide that causes a suppression in protein synthesis by halting the translation of mRNA into protein, the peptide having a Stokes radius of less than 16 Angstroms, a molecular weight, determined by SDS-PAGE, of 17 kD (indicating that the peptide is a monomer) and an isoelectric point of 7.25. The peptide of the present invention may have therapeutic advantages in halting the proliferation of abnormal or excess protein,

Growing community of inventors

New Haven, CT, United States of America

Pamela A Havre