Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Université´ D'aix-Marseille

Universitë De Bordeaux

Institut Jean Paoli & Irène Calmettes

Université De La Méditerranée - Aix-Marseille Ii

Centre Regional De Lutte Contre Le Cancer

Universite De La Mediterrance Aix-Marseille Ii

Palma Rocchi

Julie Acunzo

Philippe Barthelemy

Khalid Oumzil

Claudia Andrieu

Virginie Baylot

Maria Katsogiannou

Yang Liu

Juan Iovanna

Ling Peng

Arnaud Gissot

Yi Xia

Fanqi Qu

Jinqiao Wan

Menghua Wang

The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer.

Nucleic acids targeting TCTP for use in the treatment of chemo- or hormone-resistant cancers

The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5&#x2032; end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.

Hydrophobically modified antisense oligonucleotides comprising a triple alkyl chain

The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5&#x2032; end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.

Hydrophobically modified antisense oligonucleotides comprising a ketal group

The present invention relates to novel compounds of formula (A):  The invention also relates to process of preparation of compounds of formula (A), to composition comprising them and to their application in therapeutics and in particular in cancers.

Triazole derivatives, their preparation and their application in therapeutics

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Palma Rocchi