Memorial Sloan Kettering Cancer Center

Sloan-kettering Institute for Cancer Research

Pallav Patel

Gabriela Chiosis

Tony Taldone

Weilin Sun

Anna Rodina

Yanlong Kang

Stefan O Ochiana

Hardik J Patel

Pengrong Yan

Chenghua Yang

The disclosure relates to novel selective Grp94 inhibitors, compositions comprising an effective amount of such compounds, and methods to treat or prevent a condition, such as cancer, comprising administering to an animal in need thereof an effective amount of such compounds.

Selective Grp94 inhibitors and uses thereof

The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).

Heat shock protein binding compounds, compositions, and methods for making and using same

The disclosure relates to Compounds of Formulae (IA) and (IB), and pharmaceutically acceptable salts thereof wherein Z, Z, Z, Xa, Xb, Xc, Xd, Y, X, and Xare as defined herein, compositions comprising an effective amount of a Compound of Formula (IA) and/or (IB), and methods to treat or prevent a condition, such cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB). The disclosure further relates to compounds of Formulae (IA) and (IB) in which Xis a leaving for introducing a radiolabeled atom, such asI orI and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging. 

Hsp90 inhibitors

Substituted pyrimidine compounds and uses thereof

The disclosure relates to Compounds of Formulae (IA) and (IB): and pharmaceutically acceptable salts thereof wherein Z, Z, Z, Xa, Xb, Xc, Xd, Y, X, and Xare as defined herein, compositions comprising an effective amount of a Compound of Formula (IA) and/or (IB), and methods to treat or prevent a condition, such cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB). The disclosure further relates to compounds of Formulae (IA) and IB) in which Xis a leaving for introducing a radiolabeled atom, such asI orI and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging.

Growing community of inventors

Fresh Meadows, NY, United States of America

Pallav Patel