Sk Holdings Co., Ltd.

Sk Holding Co., Ltd.

Palanichamy Ilankumaran

Yong Moon Choi

Hunwoo Shin

Hong Wook Kim

The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1; or pharmaceutically acceptable salts thereof. The present invention also includes pharmaceutical compositions comprising an effective amount of a compound of Formula 1 in admixture with a pharmaceutically acceptable carrier or excipient. The compositions may include additional therapeutic agents for combination therapy. The present invention provides a new class of pharmaceutically active compounds, which are useful in the treatment and control of diabetes and its related metabolic diseases.

Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use

There are disclosed derivatives of 3-chromancarboxylic acid represented by formula I their pharmaceutically acceptable salts thereof and prodrugs thereof which are useful for treatment and control of non-insulin dependent diabetes mellitus (type II diabetes) and its related vascular disease as well as obesity and lipid disorders.

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Pine Brook, NJ, United States of America

Palanichamy Ilankumaran