Richter Gedeon Vegyeszeti Gyar Rt

Gyogyszerkutato Intezet

Pal Sohar

Laszlo Szporny

Eva Palosi

Gyorgy Hajos

Elemer Ezer

Gabor Bernath

Laszlo Denes

Jeno Kobor

Ferenc Fulop

Endre Csanyi

Alajos Kalman

Emilia Kiraly Nee Vida

Ferenc Folop

Pal Perjesi

The invention relates to new [1,3]oxazino[4,3-a]-isoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

[1,3]oxazino[4,3-a]-isoquinoline derivatives and pharmaceutical

The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

2H-azeto[2,1-a]-isoquinoline derivatives and pharmaceutical compositions

The invention relates to 1,6-dimesyl-3,4-dimethyl-D-mannitol of the formula (I), ##STR1## wherein Ms is mesyl and Me is methyl. This compound is a potent cytostatic agent which can be used to advantage in the therapy of various tumorous diseases. 1,6-Dimesyl-3,4-dimethyl-D-mannitol is prepared according to the invention by subjecting 3,4-dimethyl-D-mannitol to partial mesylation followed by acylation, and splitting off the acyl groups of the resulting compound of the general formula (III), ##STR2## wherein Ms and Me are as defined above and R is a saturated lower aliphatic group, with an acidic alcohol.

1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the preparation

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Budapest, Hungary

Pal Sohar