Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Pharmaceutical and Chemical Works Ltd.

Astra Aktiebolag

Aktiebolaget Astra

Danuvia Kozponti Szerszam Es Keszulekgyar

Pal Kiss

Dezso Korbonits

Gergely Heja

Endre Palosi

Ida Szvoboda Nee Kanzel

Maria Szomor Nee Wundele

Csaba Gonczi

Laszlo Ledniczky

Judit Cser Nee Kun

Gyula Papp

Laszlo Szekeres

Kalman Harsanyi

Gabor T Szabo

Tamas U Kallay

Judit Kun

Gabor Kovacs

Sandor Virag

Kalman Takacs

Rudolf Szebeni

Csaba Gonczy

Eva Benedek

Csaba Huszar

Karoly Horvath

Vera Kovacs Nee Mindler

Erzsebet Molnar Nee Bako

Attila Nemeth

Erzsebet Szalay

Karoly Ban

Ferenc Sperber

Istvan Bone

Ferenc Morasz

Livia Nagy Nee Koranyi

Sandor Garaczy

Erzsebet Szabo Nee Kardos

Karol Gyure

Gyorgy Mihalovics

Jozsef Szejtli

Gyula Sebestyen

Laszlo Tardos

Tamas Szuts

Katalin Marmarosi Nee Kellner

Imre Bata

Vera Gergely

Peter S Kormoczy

Istvan Turcsan

Agnes Stadler Nee Szoke

Emil Minker

Gabor Kalmanczhelyi

Maria Vikmon Nee Kiraly

Maria Szomor

Zoltan Vargai

Ida Szvoboda Nee Kauzel

Judit Cser

Ida Szvoboda

Csaba Gunczi

Eva Udvari

Andras Kelemen

Gyorgy Kormoczi

Mihaly Sut

Mihaly Su

Iidiko Buttkai

Arpad K Vari

Peter Gy Ri

Arpad Kvari

Ildiko Buttkai

Peter Gyri

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

The invention relates to novel diphenylpropylamine derivatives of the general formula (I). ##STR1## R.sup.1 stands for hydrogen or a methyl group; R.sup.2 stands for hydrogen, a methyl or n-decyl group;

Diphenkylpropylamines for the therapy of heart disease

The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, wherein

Process for the preparation of diphenyl ether derivatives

A process is disclosed for the preparation of a compound of the formula (XI) ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.3 alkoxy, or trifluoromethyl;

Process for the preparation of 5(6)-thio substituted benzimidazoles

Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,

Theophyllinyl-alkyl-oxadiazoles, process for the preparation thereof and

Process for the preparation of an inclusion complex of

A new process is disclosed for the preparation of a compound of the formula (VIII) ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, or trifluoromethyl;

Production of thiocyanato benzimidazoles

Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are prepared by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.

Process for the preparation of arylacetic acid derivatives

The invention relates to hydraulic flow dividing and integrating equipment, having a regulating slide valve in its flow path and calibrated throttlings in an admission channel of the flow path. The calibrated throttlings are adjustable as a function of entering liquid flow. Mobile rings are arranged on the regulating slide valve. With these simple technical arrangements, the field of application of hydraulic systems, e.g. for gear synchronization, is considerably enlarged.

Hydraulic flow dividing and integrating equipment

2-(3-phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

2-Cyano-2-(3-phenoxy-phenyl)-propionic acid amide and preparation thereof

New compounds of the formula (VIIIa) are disclosed ##STR1## wherein R.sup.1 is hydrogen, methyl or ethyl;

Esters of ortho-allylphenol useful for the preparation of arylacetic

Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are practiced by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.

Arylacetic acid derivatives

2-(3-Phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

Process for the preparation of 2-(3-phenoxy-phenyl)-propionic acid

3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.

Process for the preparation of 3-phenoxybenzenes

Growing community of inventors

Budapest, Hungary

Pal Kiss