Schering Aktiengesellschaft

Egis Gyogyszergyar Rt.

Gyogyszerkutato Intezet Kft.

Gyogyszerkutato Intezet

Richter Gedeon Vegyeszeti Gyar Rt

Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar

Biogal Gyogyszergyar

Ivax Drug Research Institute

Cyogyszerkutato Intezet Kft

Gis Gyogyszergyar Rt.

Gyogyszerkutato Intezet Kv.

Pal Berzsenyi

Ferenc Andrasi

Tamas Hamori

Imre Moravcsik

Istvan Tarnawa

Jeno Korosi

Peter Botka

Katalin Goldschmidt

Sandor Farkas

Gabor Zolyomi

Antal Simay

Istvan Elekes

Sandor Solyom

Istvan Ling

Marta Szollosy

Eszter Szentkuti

Katalin Horvath

Istvan Gyertyan

Jozsef Reiter

Tibor Lang

Pal Vago

Katalin Eszter Horvath

Melinda Gal

Anna Bakonyi

Gyorgyne Mate

Gizella Abraham

Tibor Hasko

Edit Horvath

Laszlo Szporny

Gyula Simig

Elemer Ezer

Gabor Gigler

Istvan Gacsalyi

Gabor Blasko

Judit Matuz

Lajos Toldy

Katalin Saghy

Peter Aranyi

Sandor Elek

Istvan Polgari

Andras Egyed

Peter Matyus

Jozsef Borsi

Gyorgy Somogyi

Laszlo Sebestyen

Istvan Pallagi

Zsuzsanna Fittler

Andras Bilkei-Gorzo

Geza Schneider

Sandor Boros

Karoly Tihanyi

Emese Csuzdi

Judit Bajnogel

Agnes Papp Nee Behr

Zsuzsanna Lang Nee Rihmer

Ernese Csuzdi

Arpad Lazar

Laszlo Gabor Harsing

Ildiko Varga

Peter Korosi

Hilda Botka

Zsuzsanna L Rihmer

Cecilia Salamon Haskane

Klara Daroczi Kazone

Ferenc Andrasy

Katalin G Horvath

Erzsebet Birkas

Gabor Kapus

Emese Csuzdl

Franciska Erdo

Agnes Angyal Nee Pataky

Erzsebet Szabo Nee Bagdy

Erno Koltai

Erzsebet F Birkas

Katalin Szabo Nee Pusztai

Jeno Korosi, Deceased

Peter Botka, Deceased

Erszebet Birkas

Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds

Compounds of formula I are described, their production and use in pharmaceutical agents.

Condensed 2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors

The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.

1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine

This invention relates to new 1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said benzodiazepine derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The compounds according to the invention correspond to the general formula (I), ##STR1## wherein the variables are herein below defined, and the compounds possess central nervous activities.

1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives

Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions. A process to make the 2,3-benzodiazepine derivatives includes converting starting compounds which are substituted by one or two halogen groups and have the general formula ##STR2##

2,3-Benzodiazepine Derivatives as non-competitive AMPA

3-substituted 3H-2, 3-benzodiazepine derivatives, the production and use

The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)

N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic

N-acyl-2,3-benzodiazepine derivatives pharmaceutical compositions

The invention relates to novel N-acyl-2,3-benzodiezapine derivatives and a method of treating spasms of the skeletal musculature therewith.

N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of

N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions

The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I), defined in the specification, a more complete description of the compounds may be found. The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.

N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions

The present invention relates to novel compounds of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently from each other, for hydrogen, C.sub.1-4 alkyl, phenyl, phenyl-C.sub.1-4 alkyl, piridyl or piridyl-C.sub.1-4 alkyl group;

Novel thiouracyl derivatives, pharmaceutical compositions containing

The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiaz epi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-b

The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable central nervous effect and in particular exert antiaggressive, anxiolytic, narcosis potentiating and soporific properties.

5H-2,3-benzodiazepine derivatives and pharmaceutical compositions

The invention relates to new stereoisomeric 1,4;3,6-dianhydro-2,5-diazido-2,5-dideoxy-hexitols of the Formula I. These compounds can be prepared by

1,4;3,6-Dianhydro-2,5-diazido-2,5-dideoxy-hexitols

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Budapest, Hungary

Pal Berzsenyi