Axon Therapies, Inc.

Pacesetter, Inc.

Pajhand Iranitalab

Howard Levin

Zoar Jacob Engelman

Manuel Arzadon Javier, Jr

Casey Andrew Miller

Thomas Ryan McGrath

Anisha Bapna

April C Pixley

Nicholas C VanDillen

Anne Marie Ahonen

Yongjian Wu

Anne M Shelchuk

Jianchun Yi

Shohan T Hossain

Elisabeth M Clem

Youngjian Wu

Chris Pontiga

Christopher Pontiga

Manuel Arzadon Javier

Thomas Ryan Mcgrath

Nicholas C Vandillen

Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Methods and devices for endovascular ablation of a splanchnic nerve

Embodiments of the present invention concern the timing of sending one or more commands to control circuitry of a multi-electrode lead (MEL). In one embodiment, the one or more commands are sent to control circuitry within the MEL during a predetermined portion of a cardiac pacing cycle to avoid potential problems of prior systems that were not synchronized with the cardiac pacing cycle. In one embodiment, the one or more commands are sent when cardiac tissue is refractory from a cardiac pacing pulse, to prevent the command(s) from potentially undesirably stimulating cardiac tissue. The command sending can occur such that the one or more commands are sent between instances when sensing circuitry of the implantable cardiac stimulation device is being used to obtain one or more signals indicative of cardiac electrical activity, to prevent interference between the one or more commands with the signals indicative of cardiac electrical activity that are sensed.

Systems and methods to synchronize commands sent to a multi-electrode lead (MEL) with a portion of a cardiac pacing cycle

Methods and systems are provided for configuring a Multi-Electrode Lead (MEL) that includes N groups of electrodes, with each of the N groups of electrodes including at least M electrodes, where N&#x2267;2 and M&#x2267;2. Sent via the MEL is a first communication sequence of bits that includes N groups of bits, with each of the N groups of bits corresponding to a different one of the N groups of electrodes and specifying which electrode(s), if any, within the group of electrodes is to be configured as an anode. Also sent via the MEL is a second communication sequence of bits that includes N further groups of bits, with each of the N further groups of bits corresponding to a different one of the N groups of electrodes and specifying which electrode(s), if any, within the group of electrodes is to be configured as a cathode.

Systems and methods to configure a multi-electrode lead

An implantable stimulation device that maps the location of irritable foci causing an atrial arrhythmia is provided by certain embodiments disclosed herein. The device may, for example, collect intra-cardiac data from a plurality of electrodes spatially distributed throughout a chamber of the heart. This data may be compared with data related to the location of each electrode and the electrical properties of the heart to approximate a point of origin for the atrial arrhythmia. Further embodiments may provide methods and systems for using this information to provide more efficient treatment of the atrial arrhythmia. For example, an optimized ATP pulse train may be determined based on the location of one or more irritable foci. Such an ATP pulse train may be applied to more efficiently terminate the atrial arrhythmia.

Guided atrial anti-tachycardia pacing for implanted cardiac stimulation

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San Ramon, CA, United States of America

Pajhand Iranitalab