City of Hope

Pairoj Chang

John J Rossi

John A Zaia

Edouard M Cantin

Bruce E Kaplan

Ribozymes useful to cleave HIV-1 and other viral or endogenous cellular RNAs are disclosed. Also disclosed are transformed cells which express such ribozymes and human AIDS therapy involving the administration of such ribozymes.

Ribozyme cleavage of HIV RNA

This invention provides chimeric DNA/RNA catalytic molecules useful to cleave RNA sequences.

Chimeric DNA-RNA catalytic sequences

Stable, catalytic efficient ribozymes useful, inter alia, to cleave HIV-I RNA or any other viral or endogenous cellular RNA, in vitro and in vivo, cells transformed with such ribozymes and the use of such ribozymes and cells for anti-AIDs therapy are disclosed.

Growing community of inventors

San Dimas, CA, United States of America

Pairoj Chang