Pacira Pharmaceuticals, Inc.

Paige N Davis

Kathleen D A Los

John J Grigsby, Jr

Soroush M Ardekani

Louie Daniel Garcia

Stephanie M Kurz

Jeffrey S Hall

David J Turnbull

Eran Levy

Damon A Leon

Alisha R Simonian

Some embodiments of the present application are related to multivesicular liposome formulations comprising high concentration of bupivacaine for the purpose of preventing, treating or ameliorating pain, for example, post-surgical pain for an extended period of time. Processes of making and administering bupivacaine encapsulated multivesicular liposome formulations (BUP-MVLs) and their uses as medicaments are also provided.

Bupivacaine multivesicular liposome formulations and uses thereof

Some embodiments of the present application are related to multivesicular liposome (MVL) formulations encapsulating dexamethasone or an ester or an ester salt thereof, for example, dexamethasone sodium phosphate (DSP) that may provide about 3-28 days extended release of dexamethasone. Processes of making and administering dexamethasone encapsulated multivesicular liposome formulations and their uses for treating pain or inflammation are also provided.

Multivesicular liposome formulations of dexamethasone

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

Manufacturing of bupivacaine multivesicular liposomes

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San Diego, CA, United States of America

Paige N Davis