Abbott Laboratories Corporation

Padmavathy Krishnan

Pradip Mukerji

Suzette Pereira

Tapas Das

Tapas Kumar Das

Amanda E Leonard

Disclosed are antibodies that specifically recognize &#x394;5-desaturase, methods of producing the antibodies, nucleotides and polypeptides for producing the antibodies, and methods of using the antibodies. The &#x394;5-desaturase-specific antibodies provide improved methods of detecting &#x394;5-desaturase in a sample.

Antibodies against delta-5 desaturase and uses thereof

The subject invention relates to the identification of a gene involved in the elongation of polyunsaturated fatty acids containing unsaturation at the carbon 9 position (i.e., '&#x394;9-elongase') and to uses thereof. In particular, &#x394;9-elongase may be utilized, for example, in the conversion of linoleic acid (LA, 18:2n-6) to eicosadienoic acid (EDA, 20:2n-6). The production of dihomo-&#x3b3;-linolenic acid (DGLA, 20:3n-6) from eicosadienoic acid (EDA, 20:2n-6), and arachidonic acid (AA, 20:4n-6) from dihomo-&#x3b3;-linolenic acid (DGLA, 20:3n-6) is then catalyzed by &#x394;8-desaturase and &#x394;5-desaturase, respectively. AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

Elongase gene and uses thereof

The present invention is related to isolated polynucleotides encoding a delta-8 desaturase, delta-8 desaturases encoded by the isolated polynucleotides, expression vectors containing the isolated polynucleotides, host cells containing the expression vectors and methods for producing delta-8 desaturases and polyunsaturated fatty acids.

Delta-8 desaturase genes, enzymes encoded thereby and uses thereof

The present disclosure relates to isolated polynucleotides encoding a delta 9-elongase, delta 9-elongases encoded by the isolated polynucleotides, expression vectors comprising the isolated polynucleotides, host cells comprising the expression vectors, and methods for producing delta 9-elongase and polyunsaturated fatty acids.

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Hilliard, OH, United States of America

Padmavathy Krishnan