Other

Padmanabhan P Nair

Ramgopal Nair

Sudhir K Dutta

Tarun Mullick

A miniature ingestible capsule has multiple therapeutic or diagnostic operations that can be performed. These functions are controlled by a combination of an outside control, a pose beacon and through information relayed from an imagining array and transmitter. These functions can be in a separate capsule without an imaging array or within the same capsule with an imaging array. Typically, there is one function performed in addition to imaging. These functions can include suction and spray capabilities, ultrasound sensor, lithotripsy, laser, heat, electrocautery, BICAP, biopsy forceps, a needle knife snare cautery (cold and hot with continuous or pulsed current for cutting and coagulation), with a basket, and fine needle aspiration with various wheels and fins and motors controlled externally and other tools to be used in humans. All of these tools can be attached to a retractable arm. Also, they can be used on an elevator device that lifts them, allowing for an extra 180&#xb0; of movement.

Miniature ingestible capsule

A non-invasive method of testing for inflammatory bowel disease using a domain specific monoclonal antibody is described. A unique 18 residue amino acid sequence overexpressed in COX-2 has been identified for making and using the monoclonal antibody.

Polypeptide useful for a non-invasive test for inflammatory bowel disease

A miniature ingestible imaging capsule having a membrane defining an internal cavity and being provided with a window is provided. A lens is disposed in relation to said window and a light source disposed in relation to the lens for providing illumination to outside of the membrane through the window. An imaging array is disposed in relation to the lens, wherein images from the lens impinge on the imaging array. A transmitter is disposed in relation to the imaging array for transmitting a signal from the imaging array to an associated transmitter outside of the membrane. The lens, light source imaging array, and transmitter are enclosed within the internal cavity of the capsule.

A method for isolating viable, biologically substantially pure exfoliated fecal colonocytes at normal ambient temperature is described. Immunocoprocytes and inflammatory cells indicative of certain gastrointestinal conditions and a noninvasive method for detecting colorectal cancer are set forth. Composition of transport and suspension media for isolation of colonocytes are detailed.

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Ellicott City, MD, United States of America

Padmanabhan P Nair