Alza Corporation

Other

Alta Corporation

Padmanabh Bhatt

Noymi Yam

Atul D Ayer

Evangeline Cruz

David E Edgren

Andrew C Lam

Michael A DesJardin

Phillip R Nixon

Sylvia L Seroff

Adam Zhong

Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between a semi-permeable wall and drug layer comprising the device.

Controlled delivery of active agents

Dosage forms and methods for the controlled release of antidepressives, such as exemplified by phenoxyethyl substituted-1,2,4-triazolones, as a suspension or a slurry over a prolonged period of time are described.

Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones

Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.

Methods for providing effective reboxetine therapy with once-a-day dosing

Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing

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Saratoga, CA, United States of America

Padmanabh Bhatt