Verve Therapeutics, Inc.

Sumitomo Dainippon Pharma Co., Ltd.

Padma Malyala

Kallanthottathil G Rajeev

Caroline Reiss

Alexandra Chadwick

Souvik Biswas

Lisa N Kasiewicz

Hitoshi Ban

Yukihiro Nishio

Marcus Wong

Bilikallahalli K Muralidhara

Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.

Compositions and methods for targeted RNA delivery

The present specification relates to adenine conjugate compounds represented by the formula (1), wherein A, L, L, X, R, R, R, and m are as defined herein, or their pharmaceutically acceptable salts. Compounds of formula (1) have immunostimulating properties and may therefore be useful in therapy, for example as vaccine adjuvants. The present specification also relates to a process for preparing adenine conjugate compounds and pharmaceutically acceptable salts thereof, and to pharmaceutical compositions comprising adenine conjugate compounds and their pharmaceutically acceptable salts. 

Adenine conjugate compounds and their use as vaccine adjuvants

Growing community of inventors

Burlington, MA, United States of America

Padma Malyala