Novartis Ag

Glaxosmithkline Biologicals Sa

Padma Malyala

Derek T O'Hagan

Manmohan Singh

Siddhartha Jain

Jina Kazzaz

Janet Wendorf

Dong Yu

Kathryn Hashey

Marcelo Samsa

Olga Slack

Alan Stokes

Rashmi Jalah

Derek T O'HAGAN

Nucleic acid based vaccine constructs encoding Lyssaviral antigens are useful in preventing and treating diseases. Self-amplifying RNA molecules encoding Lyssaviral antigens provide potent and long-lasting immunity.

Lyssavirus antigen constructs

In one aspect, the present invention provides sterile microparticle compositions comprising biodegradable microparticles, which comprise at least one biodegradable polymer. In other aspects, the present invention provides methods of making and using such compositions as well as articles of manufacture and kits containing the same.

Irradiated biodegradable polymer microparticles

The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) at least first and second adjuvants, wherein the first adjuvant comprises microparticles and wherein the second adjuvant comprises an imidazoquinoline compound, and (c) a pharmaceutically acceptable excipient, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.

Compositions for inducing immune responses

Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.

Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions

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Santa Clara, CA, United States of America

Padma Malyala