Laboratorios Lesvi, S.l.

Pablo Pablo Alba

Carmen Úbeda Pérez

Ignacio Díez Martín

Ignacio Diez Martin

Carmen Ubeda Perez

Ignacio DÍEZ MARTÍN

Carmen ÚBeda PÉREZ

Carmen ÚBeda Pérez

This invention relates to a an orally disintegrating tablet obtainable by direct compression of a dry powdered mixture, said mixture comprising up to 15% by weight of calcium silicate, at least 50% of a diluent, a disintegrant agent and an active ingredient. It also relates to a process for preparing the tablets by homogeneous blending the specific excipients in powder form and subsequent direct compression of the mixture. Said tablets disintegrate quickly in the cavity of the mouth, in particular in less than 15 seconds.

Orodispersible tablets

The invention relates to a solid formulation for the oral administration of olanzapine that comprises a core of anhydrous olanzapine Form I or a pharmaceutically acceptable salt thereof and, optionally, pharmaceutically acceptable excipients, said core being coated with a functional polymer that acts as filmogenic agent. The method for obtaining it comprises: i) providing anhydrous olanzapine Form I or a salt thereof and, optionally, pharmaceutically acceptable excipients in solid form; ii) providing a functional polymer that acts as filmogenic agent; iii) preparing a dispersion of said functional polymer in an aqueous medium,&#x2014;and applying the dispersion obtained in step iii) onto the solid form of step i).

Oral formulation of anhydrous olanzapine form I

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Cornella de Llobregat Barcelona, Spain

Pablo Pablo Alba