Rca Inc.

Rca Thomson Licensing Corp.

Thomson Consumer Electronics Inc.

Rca Licensing Corporation

David Sarnoff Research Center, Inc.

Sarnoff Corporation

Addressograph Multigraph Corporation

Delsys Pharmaceutical Corporation

Thomson Licensing S.a.

Am International Incorporated

Delsys Pharmaceautical Corporation

Pabitra Datta

Ronald N Friel

Eugene Samuel Poliniak

Randall Eugene McCoy

Timothy Allen Pletcher

Peter M Ritt

Howard Christopher Rivenburg

Harry R Stork

Christopher Just Poux

Nitin Vithalbhai Desai

George H Riddle

Brian Thomas Collins

Robert E Simms

Carl C Steinmetz

Nitin V DeSai

Bawa Singh

Grzegorz Kaganowicz

Hoi Cheong Sun

Nitin V Desai

Wilber Clarence Stewart

Vladimir Sinisa Ban

Dennis Lee Matthies

Aaron W Levine

James Regis Matey

Virgil W Westdale

John J Moscony

John A Van Raalte

Edward Richard Garrity, Jr

Hirohisa Kawamoto

Richard LaPeruta, Jr

Charles M Wetzel

George M Ehemann, Jr

Abraham Goldman

Dennis Ronald McCarthy

Leonard P Fox

Robert P Thompson

Kangning Liang

John Novotny

Steven Anthony Colbert

Gregory James Cohee

Nestor A Arroyo

William Yat Chung Chiang

Dominic S Rosati

Nitin Vithalbhi Desai

Nitin Vithabhi Desai

Evan Serge Baltazzi

Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.

Method and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate

In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.

Inhaler apparatus with modified surfaces for enhanced release of dry powders

In accordance with the present invention, a method of electrophotographically manufacturing a luminescent screen assembly on an interior surface of a faceplate panel,of a color CRT,includes the steps of: coating the surface of the panel with a conductive solution to form a volatilizable organic conductive layer,, and overcoating the organic conductive layer,with a photoconductive solution to form a volatilizable photoconductive layer,. The conductive solution comprises the organic polymer 3,4-polyethylene dioxythiophene polystyrene sulphonate (PEDT/PSS); a methanol-soluble polymer or co-polymer selected from the group consisting of polyvinylpyrrolidone (PVP), poly (vinyl pyridine-co-vinyl acetate) (PVPy-VAc), polymethacrylic acid (PMAA), poly (hydroxyethylacrylate-co-methacrylic acid) (PHEA-MAA) and poly (hydroxyethyl methacrylate) (PHEMA) to reduce organic residue; and a solvent.

Humidity and temperature insensitive organic conductor for electrophotographic screening process

A method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, an apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.

Method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.

Method for electrostatically depositing a medicament powder upon

Method and apparatus for electrostatically depositing a medicament

In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.

Inhaler apparatus with modified surfaces for enhanced release of dry

The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate. In other preferred embodiments, the inhaler apparatus further comprises a third conductive layer positioned below the substrate, and the voltage source is preferably connected to the second conductive layer above the substrate and the third conductive layer below the substrate In another aspect, the present invention provides a method for dispensing a medicant from an inhaler, comprising: (a) providing an inhaler with a substrate having a medicant deposited thereon, the substrate comprising a conductive layer and a dielectric layer and a voltage source connected to said conductive layer; and (b) actuating the voltage source.

Inhaler apparatus with an electronic means for enhanced release of dry

The present invention provides an acoustic dispenser for propelling objects toward a substrate, together with methods of use of the dispenser. The acoustic dispenser uses a source of acoustic vibration and a membrane for the application of acoustic vibration wherein the objects are propelled from the membrane to a substrate. The acoustic dispenser and the methods of the invention can be used with numerous types of objects. In some embodiments, the objects are particles in a dry powder, which can include, for example, a pharmaceutically active ingredient. In other embodiments, the objects are beads, which preferably have an average diameter of about 100 to about 300 microns. Additionally, the acoustic dispenser can be used with more than one type of object, for example, two types of objects such as beads and dry powder. In some instances, the acoustic dispenser further comprises a membrane for separating one type of object from the other based on size, whereby one type of object is separated from the other prior to deposition.

Acoustic dispenser

Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.

Apparatus for electrostatically depositing a medicament powder upon

A tribo-inhaler having a container portion for electrostatically retaining a predefined dose of medicament powder, where the medicament is tribo-electrically charged; and apparatus, attached to the container portion, for extracting said medicament powder from the container portion. The container portion contains a plurality of polymeric beads that have diameters of approximately 50 to 200 microns. Each of the polymeric beads has a specific quantity of dry powder medicament electrostatically adhered to its surface. To remove the medicament from the cavity, a patient merely inhales air through the container portion. The air flow forcefully moves the beads within the container portion causing the medicament to dislodge from the beads and be carried by the air flow into the lungs of the patient.

Inhaler apparatus using a tribo-electric charging technique

In accordance with the present invention, a method of electro-photographically manufacturing a luminescent screen assembly on an interior surface of a faceplate panel 12 for a color CRT 10 includes the steps of coating the interior surface of the faceplate panel with a volatilizable, organic conductive solution to form an organic conductive (OC) layer 32, and overcoating the OC layer with a volatilizable, organic photoconductive solution to form an organic photoconductive (OPC) layer 34. The step of overcoating the OC layer to form the OPC layer is improved by the substeps of: grounding the OC layer; providing an organic photoconductive (OPC) solution comprising a resin, an electron donor material and electron acceptor material, and a suitable solvent; and spraying electrostatically-charged droplets of the OPC solution onto the OC layer, with at least one electrostatic spray gun 47, to provide an OPC layer, having uniform thickness, overlying the OC layer.

CRT electrophotographic screening method using an organic

A method of manufacturing a luminescent screen assembly on an interior surface of a faceplate panel 12 for a color CRT 10 includes the steps of uniformly applying a solution of a material to form an organic conductive (OC) layer and overcoating the OC layer with a solution to form an organic photoconductive (OPC) layer, on the interior surface of the faceplate panel. The OPC layer 34 is conditioned by directing a stream of dry gas thereon to warm the OPC layer to a preheat temperature, while maintaining the panel at a panel temperature less than the preheat temperature. The OPC layer is exposed to IR radiation to rapidly increase the temperature of the OPC layer to a curing temperature, greater than the preheat temperature, to remove some of the volatilizable constituents from the OPC layer, without substantially increasing the temperature of the panel. The OPC layer is then cooled by directing at least one stream of cool gas onto the surface thereof, to lower the temperature of the OPC layer to a subsequent processing temperature.

Method of manufacturing a luminescent screen for a CRT by conditioning a

In accordance with the present invention, an apparatus for developing a latent image formed on a photoreceptor, which is deposited on an interior surface of an output window of a display device, is disclosed. The developing apparatus includes a developing chamber, having a support surface for supporting the output window, a screen structure material reservoir for storing, deagglomerating and feeding the screen structure material, and a triboelectric gun assembly communicating with the reservoir. The gun assembly triboelectric charges and imparts a desired charge polarity to the screen structure material. The gun assembly further includes at least one material dispersing nozzle spaced from the support surface for distributing the charged material for deposition onto the latent image.

CRT developing apparatus

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Cranbury, NJ, United States of America

Pabitra Datta