Bionumerik Pharmaceuticals, Inc.

P Seetharamulu

Frederick H Hausheer

Kochat Haridas

Dhanabalan Murali

Dasharatha Gauravaram Reddy

Pavankumar Nv Petluru

Shijie Yao

This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist of the novel compounds in solution or suspension with one or more pharmaceutical excipients or dilutes.

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San Antonio, TX, United States of America

P Seetharamulu