University of Texas System

Ozlem Kulak

Lawrence Lum

Chuo Chen

Xiaofeng Wu

Xuewu Zhang

The present disclosure provides compounds that may be useful for inhibiting the Tankyrase enzyme. In some aspects, these compounds are useful in the treatment of a disease or disorder related to the misregulation of Tankyrase enzyme such as cancer, degenerative diseases, or fibrotic diseases. Also provided herein are compounds may also be used to prevent the elongation of the telomere in a cell.

Indolinyl-sulfonamide inhibitors of tankyrase and methods of use thereof

Inhibitors of luciferase enzymes are disclosed and find use in multiplexed assays using multiple luciferases and multiple inhibitors, in both in vitro and in vivo embodiments.

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Dallas, TX, United States of America

Ozlem Kulak