Hybridon, Inc.

The Norwegian Radium Hospital Research Foundation

Abbott Laboratories Corporation

Oystein Fodstad

Sudhir Agrawal

Olav Engebraaten

Gunhild Maelandsmo

Eivind Hovig

Eric Von Hofe

Gunnar Kvalheim

Gunnar Kvalbeim

Meng Yu Wang

Olav Engebraten

Siri Juell

The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to specific antigen determinants in the target-cell membranes. Incubation of the cell suspension with a mild detergent and/or second set of antibodies or antibody fragments, prelabeled or not with fluorescent agents, metallocolloids, radioisotopes, biotincomplexes or certain enzymes allowing visualization, with dramatically increase the specificity of the method. The method can further be used for isolation of the target-cells by magnetic field application and kit for performing the method according to the invention is described.

Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations

A method for killing unwanted target cells in a cell population comprising nucleated cells harvested from peripheral blood, or CD-34+ or similar early progenitor cells selected from the above nucleated cells or from bone marrow aspirates, in which method the cell population is in vitro or in vivo exposed to two or more immunotoxins selectively killing the malignant cells, is described. Furthermore the invention relates to the mixture of immunotixins, the use of the mixture and a kit for performing the method.

Method of killing target cells in harvested cell populations with one or more immuno-toxins

Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.

CAPL-specific oligonucleotides and methods of inhibiting metastatic

CAPL-specific oligonucleotides and method of inhibiting metastatic cancer

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Oslo, Norway

Oystein Fodstad