University of California

Agensys, Inc.

Other

California Institute of Technology

University

Owen N. Witte

Robert E. Reiter

Owen N Witte

Robert E Reiter

Charles L Sawyers

Karen A Klein

Zhigang Weng

Douglas C Saffran

Aya Jakobovits

Arthur B Raitano

Caius G Radu

Michael E Jung

James R Heath

Michael A Teitell

Nagichettiar Satyamurthy

Antoni Ribas

David J Rawlings

Yan Xu

Johannes Czernin

Peter M Clark

Thomas A Zangle

Gabriel A Kwong

Daina Burnes Linton

Blanca Graciela Flores Castillo

Nikolai M Evdokimov

Evan David Nair-Gill

Chengyi J Shu

Lu Q Le

Janusz H S Kabarowski

Kui Zhu

Charles L Sawyer

Satoshi Tsukada

James Konopka

Susan Watanabe

In certain embodiments methods of identifying T cell receptors that respond to specific target cell antigens are provided, where the methods comprise providing a substrate bearing a plurality of target cells (e.g., mammalian cells); contacting the target cells on the substrate with CD8+ T cells; and using label-free optical imaging to identify an increase in mass of a T-cell and/or a decrease in mass of a target cell, where an increase in mass of a T cell and/or a decrease in mass of a target cell is an indicator that said T cell bears a T cell receptor activated by antigens presented on said target cell.

Selecting and isolating desirable t lymphocytes by change in mass responses

The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.

Positron emission tomography probe to monitor selected sugar metabolism in vivo

The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

PSCA: prostate stem cell antigen and distinguishing androgen receptor negative prostate cancer from benign prostatic hyperplasia

PSCA: prostate stem cell antigen and uses thereof

Polynucleotide-encoded capture agents for target detection and in particular modular polynucleotide-capture agents comprising a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion, and related compositions methods and systems.

Capture agents and related methods and systems for detecting and/or sorting targets

Compounds for use as PET probes and methods for synthesizing and using these, comprising [F]D-FAC and other cytosine and adenosine analogs.

Positron emission tomography probes for imaging immune activation and selected cancers

The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.

Mouse models of human prostate cancer

Methods for inhibiting the growth of cancer cells expressing PSCA

PSCA: prostate stem cell antigen and uses thereof in pancreatic cancer

Mouse prostate stem cell antigen and uses thereof

Mouse models of human prostate cancer progression

The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.

E25A protein, methods for producing and use thereof

Growing community of inventors

Sherman Oaks, CA, United States of America

Owen N Witte