Astex Therapeutics Limited

Merck Sharp + Dohme B.v.

Owen Callaghan

Miles Stuart Congreve

Andrew Madin

Christopher William Murray

Valerio Berdini

Gordon Saxty

Maria Grazia Carr

Adrian Liam Gill

Michael Alistair O'Brien

Charlotte Mary Griffiths-Jones

Gilbert Besong

Richard David Taylor

Emma Vickerstaffe

Joris M Swaak

Marco A Voogsgerd

Mario A A De Zeeuw

Rajdeep Kaur Nijjar

Andrew Pike

Gilbert Ebai Besong

David Richard Newell

Michael Alistair O'brien

Michael Alistair O'BRIEN

Cornelis P M Govers

Cornelius P M Govers

Klaas Sipkens

Jesper Laursen

Mario AA De Zeeuw

Cornelis PM Govers

A vaginal ring applicator having a polymeric barrel and at least one friction reducing agent, wherein the barrel is a flattened cylinder having two slightly curved and opposing sides connected by two arcs, wherein the barrel extends between an insertion end and a plunger end; and a plunger extending between distal and proximal ends, wherein the distal end of the plunger engages the plunger end of the barrel and wherein the plunger fits telescopically within the barrel.

Vaginal ring applicator

The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Bicyclic heterocyclic compounds as FGFR inhibitors

The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.

Imidazo[1,2-a]pyridine compounds for use in treating cancer

The present invention relates to FGFR pharmacophores, and in particular to compounds which are capable of binding to FGFR with greater affinity than their binding to VEGFR and methods of identifying such compounds using the pharmacophore. The present invention further relates to compositions, methods and uses of the compounds and the pharmacophores disclosed herein.

FGFR pharmacophore compounds

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Den Bosch, Netherlands

Owen Callaghan