F.i.s. Fabbrica Italiana Sintetici S.p.a.

Other

Fidia Farmaceutici S.p.a.

Consiglio Nazionale Delle Richerche

Phf S.a.

Dinamite

Consiglio Nazionale Delle Ricerche - Dinamite Spa

Ottorino De Lucchi

Stefano Tartaggia

Andrea Caporale

Andrea Castellin

Pierluigi Padovan

Marco Galvagni

Riccardo Motterle

Stefano Fogal

Clark Ferrari

Alex Comely

Marta Pontini

Giorgio Modena

Simone Zaramella

Rosa Maria Moreno

Ettore Camera

Francesco Fontana

Paolo Stabile

Monica Campisi

Elena Brasola

Siro Serafini

Alessandro Falchi

Emiliano Rossi

Riccardo Beninatto

Terry Shi

Enrico Rosso

Fabiola Filippuzzi

Fabiola Filipuzzi

Sam Lou

Giuseppe Borsato

Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine. 

Efficient process for the preparation of sitagliptin

Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.

Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid

Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.

Convenient process for the preparation of statins

Disclosed are photocrosslinked hyaluronic acid (HA) derivatives consisting of HA, a bifunctional polyethylene glycol (PEG) spacer which is triethylene glycol, and a photoreactive compound selected from a coumarin derivative and propiophenone.

Photocrosslinked hyaluronic acid derivatives, and the preparation process and use thereof

Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.

Process for the preparation of eslicarbazepine and eslicarbazepine acetate

An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) wherein Ris propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV) by an amination reaction to a compound of formula (III), which is then protected to provide a compound of formula (II), which is then alkylated to provide the compound of formula (I).

Process for the preparation of key intermediates of omarigliptin

Described herein are intermediate compounds and derivatives thereof that can be synthesized during the preparation of 2,4,5-trifluorophenylacetic acid and derivatives thereof.

Intermediate compounds and derivatives thereof involved in the preparation of 2,4,5-trifluorophenylacetic acid compounds and derivatives thereof

The present invention relates to a new process for the preparation of 2,4,5-trifluorophenylacetic acid and salts thereof by new synthetic intermediates.

Process for the preparation of 2,4,5-trifluorophenylacetic acid

A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.

Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib

An alternative method for the preparation of Erlotinib through a new chemical reaction for the preparation of the 4-(3-aminophenyl)-2-methyl-3-butyn-2-ol key intermediate of formula (IV) according to the following scheme. 

Method for the preparation of erlotinib

The present invention relates to a process for the preparation of Brinzolamide, or 2H-thieno[3,2-e]-1,2-thiazin-6-sulfonamide, 4-(ethyl amino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-via intermediates 2,3-dihydro-4H-thieno[3,2-e]-1,2-thiazin-4-ones, 1,1-dioxide. Further objects of the present invention are the intermediates mentioned above and other intermediates of the synthesis.

Process for the preparation of brinzolamide

A process for the preparation of isosorbide-2-mononitrate (I) ##STR1## from isosorbide-2,5-dinitrate (II) ##STR2## The isosorbide-2,5-dinitrate (II) is treated, in a reaction medium consisting of an aqueous organic solvent, with salts of metals of low oxidation state. Isosorbide-2-mononitrate (I) is obtained with high selectivity.

Process for the selective preparation of isosorbide-2-mononitrate from

A selective process for the preparation of isosorbide-5-mononitrate (I) ##STR1## from isosorbide-2,5-dinitrate (II) ##STR2## Said preparation is carried out by treating isosorbide-2,5-dinitrate with a suitable reduction system in the presence of not easily oxidizable coordinating metal ions.

Growing community of inventors

Padua, Italy

Ottorino De Lucchi