Hoechst Aktiengesellschaft

Hoechstaktiengesellschaft

Nobel Hoechst Chimie

Hoechst Aktiengesellcshaft

Otto Mauz

Siegfried Noetzel

Klaus Sauber

Ernold Granzer

Norbert Mayer

Bernhard Neumann

Gerhard Pfahler

Yani Christidis

Edgar Fischer

Gunther Nowy

Eberhard Prinz

The invention relates to crosslinked polymers based on polyvinyl acylate or polyvinyl alcohol and having crosslinking agent units which are derived from crosslinking agents of the general formulae ##STR1## These products, inter alia, are particularly hydrolysis-resistant and can have high crosslinking densities. The invention also relates to a process for preparing these polymers and to their use in chromatography and as carriers for biologically active substances.

Carrier bonded enzymes and a process for their preparation

Crosslinked polymers which are produced from monomers containing epoxide groups, crosslinking monomers and, where appropriate, other monoethylenically unsaturated monomers are composed of principally spherical porous particles and are very suitable as carrier materials for the immobilization of biologically active substances.

Crosslinked polymers and a process for their preparation

The invention relates to crosslinked polymers based on polyvinyl acylate or polyvinyl alcohol and having crosslinking agent units which are derived from crosslinking agents of the general formulae ##STR1## and/or ##STR2## These products, inter alia, are particularly hydrolysis-resistant and can have high crosslinking densities. The invention also relates to a process for preparing these polymers and to their use in chromatography and as carriers for biologically active substances.

N,N'-divinylalkylurea crosslinked polymers, a process for their

Modified polymers based on polyvinylene carbonate and/or polyhydroxymethylene are prepared containing covalently bonded units derived from particular alkoxylated compounds. Polymerization is carried out in the presence of the alkoxylated compounds and a particular dispersion stabilizer. The modified polymer is suitable as a carrier for biologically active substances or for affinity chromatography.

Polymers based on polyvinylene carbonate and/or polyhydroxymethylene as

The invention relates to modified polymers based on polyvinylene carbonate and/or polyhydroxymethylene, the modification being effected by particular alkoxylated compounds incorporated into the polymer. These polymers, for the preparation of which, according to the invention, particular dispersion stabilizers are used, are suitable, inter alia, as carriers for biologically active substances or for affinity chromatography.

Preparation of polymer based on polyvinylene carbonate and/or

Polyvinylene carbonate and polyhydroxymethylene, processes for their

Crosslinked polymers which are produced from monomers containing glycerol carbonate groups, crosslinking monomers and, where appropriate, other monoethylenically unsaturated monomers are composed of principally spherical porous particles and are very suitable as carrier materials for the immobilization of biologically active substances.

Crosslinked polymers with carbonate ester groups, and a process for

The invention relates to bead polymers based on monomers of the formula ##STR1## in which X is hydrogen or methyl, R denotes an aliphatic hydrocarbon radical having 1 to 12 carbon atoms, and Y denotes OH or NH.sub.2, which have been prepared using a special dispersion stabilizer. They are particularly distinguished by high porosity and are very suitable as carrier materials for biologically active substances.

Macroporous bead polymers, a process for their preparation and their use

The invention relates to bead polymers based on vinylene carbonate which are distinguished, in particular, by high porosity and which are well suited as carrier materials for biologically active substances. The preparation of these bead polymers is carried out, according to the invention, in the presence of certain dispersion stabilizers.

Vinylene carbonate polymers, a process for their preparation and their

Acetoacetic acid pentaerythrite phosphite ester may be easily mixed with polymers and improves their processing, color and weather stability.

Acetoacetic acid pentaerythrite phosphite ester

Bis(hydroxyphenyl)-alkanoic acid esters the phenyl radicals of which are alkylated twice are prepared by alkylation of corresponding compounds carrying one alkyl radical at the nucleus, using isobutylene as alkylating agent. The alkanoic acid esters are obtained in crystalline form and are suitable as stabilizers for polyolefins.

Bis(hydroxy-di-tert.butylphenyl)-alkanoic acid esters

Piperidone derivatives of the formula ##STR1## in which R.sup.1 and R.sup.2, which may be identical or different, each represent a hydrogen atom or a halogen atom or an alkyl or alkoxy group of 1 to 9 carbon atoms, process for preparing them and pharmaceutical preparations consisting of, or containing, these compounds.

Substituted hydroxyphenyl-piperidones

When replacing the low molecular mercaptan used as a catalyst in the known process for preparing condensation products of phenols and acetoacetic acid esters by an n-alkyl mercaptan having of from 8 to 20 carbon atoms, the yield is improved and the reaction time reduced, while the working up of the reaction batch is simultaneously improved.

Process for preparing condensation products of phenols and acetoacetic

Pharmaceutical compositions acting on the metabolism which contain as active substance bis(4-hydroxy-phenyl)alkanoic acids corresponding to the formulae I and II ##STR1## wherein R.sup.1 and R.sup.2 wich may be identical or different, each stands for a hydrogen or halogen atom or an alkyl group having 1 to 4 carbon atoms, R.sup.3 stands for a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R.sup.4 stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenyl-alkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having 5 to 8 carbon atoms or a group of the formula ##STR2## in which Z and Z', which may be identical or different, each stands for hydrogen, alkyl of 1 to 18 carbon atoms, phenyl or cycloalkyl of 5 to 8 carbon atoms, or both together with the nitrogen atom may form a heterocyclic ring, R.sup.6 stands for an alkylene radical having 2 to 12 atoms and n stands for zero or an integer of 1 to 6, and process for preparing them.

Lowering lipid and sugar levels in the blood with a

Pharmaceutical compositions acting on the metabolism which contain as active derivatives of the 4-hydroxy-3,5-di-akylphenyl-propionic acid corresponding to the formula I and II ##EQU1## wherein R.sub.1 and R.sub.2 which may be identical or different, each stands for an alkylradical having 1 to 8 carbon atoms,

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Liederbach, Germany

Otto Mauz