Deutsche Gold- Und Silber-scheideanstalt Vormals Roessler

Degussa Aktiengesellschaft

Asta Medica, Aktiengesellschaft

Asta Pharma Aktiengesellschaft

Otto Isaac

Reinhold Carle

Dieter Sauerbier

Jurgen Engel

Klaus Posselt

Horst Uthemann

Heribert Offermanns

Klaus Thiemer

Eckhard Milsmann

Karl-Heinz Mangartz

Klaus Molge

Gerhard Oepen

Uwe-Peter Dammann

Wolfgang P Brade

Norbert Seifried

Bernd Dolle

Camomile oil having a high cis- and trans-spiroether content is produced in a process which includes steam distillation or aqueous distillation of fresh camomile or an extraction residue of camomile.

Camomile oils having a high content of natural poly-ynes and process for their preparation

Camomile oils having a high natural poly-ynes content and process for

Ifosfamide lyophilizate consisting substantially of ifosfamide and 0.1 to 17 parts by weight of a hexitol.

Ifosfamide lyophilisate and process for its preparation

Solid oral ifosfamide formulations comprising a capsule containing a mass which consists essentially of the active substance ifosfamide and microcrystalline cellulose, or in the form of tablets which contain, in relation to one part by weight of ifosfamide,

Solid oral dosage forms of ifosfamide

An ifosfamide-mesna lyophilizate consists substantially of ifosfamide, 0.1-1.0 parts by weight of mesna and 0.1 to 17 parts by weight of hexitol. The product is obtained by freeze drying an aqueous or aqueous-ethanolic solution of ifosfamide and mesna.

Ifosfamide-mesna lyophilizate and process for its preparation

Improved camomile extracts are obtained by extraction of fresh camomile flowers with aqueous lower alkanols and wthout a subsequent heat treatment.

Process for producing storable camomile extracts rich in active

This invention relates to the production of camomile extracts rich in flavone by extracting ordinary camomile drug together with added camomile wing petals.

Process for the production of camomile extracts rich in flavones

There is provided a process for the recovery of pure hellebrin which comprises extracting a defatted hellebrin extract dissolved in a water-alkanol mixture or water-acetone mixture with a mixture of a lower alkanol or acetone and di-, tri-, or tetrachloromethane (or dichloroethane) evaporating the extraction agent in a vacuum and then heating with ethanol until the deposition of the first hellebrin crystals begins.

Process for the recovery of pure hellebrin

There are prepared compounds corresponding to the general formula: ##STR1## in which R represents a 2,2-dimethylethenyl; isopropyl; nonyl; a C.sub.3 -C.sub.6 -cycloalkyl radical; a phenyl group substituted by at least one nitro group, or a C.sub.1 -C.sub.6 -alkyl group containing a morpholine group attached thereto, said morpholine ring being substituted zero to twice by C.sub.1 -C.sub.6 -alkyl groups; R.sub.3 is --CHO or --CH.sub.2 OH, their optically active forms and their salts. The compounds have cardioactivity e.g., bradycardic effect and have local anethetic, spasmolytic and antiarythmic activity.

Acyl derivatives of hellebrigenin

Compounds are prepared of the formula ##STR1## The compounds of the invention possess valuable pharmacodynamic properties. They especially have a positive inotropic effect which is particularly noted in oral or enteral application. In contrast to the known compounds the compounds of the invention have more favorable pharmacological or pharmaceutical properties.

Derivative of desglucohellebrin and therapeutic use

The main sapogenins in the roots and rhizomes of Helleborous species are recovered by treating the roots and/or rhizomes or drugs or extracts made therefrom with cellulase, hemicellulase or .beta.-glucosidase.

Process for recovering the main sapogenins from the roots of rhizomes of

The main sapogenin of the roots and rhizomes of Helleborus species is used in medicine, especially to treat ulcers.

Medicine containing the main sapogenin of helleborus

.alpha.- Bisabolol of plant origin is purified by being treated with alkali hydroxide, alkali alcoholate, alkali carbonate, alkali bicarbonate, alkaline earth hydroxide, alkaline earth oxide or aluminium hydroxide. Preferably activated carbon is also used in the purification. Preferably the .alpha.-bisabolol is treated with pure nitrogen gas before the alkali treatment.

Growing community of inventors

Hanau, Germany

Otto Isaac