Bayer Aktiengesellschaft

Otto Behner

Siegfried Goldmann

Hartmund Wollweber

Siegfried Zaiss

Bruno Rosen

Friedrich Hoffmeister

Wilhelm Stendel

Egbert Wehinger

Rudolf Schohe-Loop

Bodo Junge

Thomas Glaser

Hans-Georg Heine

Jean-Marie-Viktor De Vry

Henning Sommermeyer

Klaus Urbahns

Reilinde Wittka

Siegismund Schutz

Hartmut Wollweber

Peter Andrews

Ulrich Horlein

Hans Werner Schubert

The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.

Use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters as medicaments

1,4-dihydropyridine-3,5-dicarboxylic acid esters in treatment of

The invention relates to the new dimethyl 4-(4-chloro-3-trifluoromethylphenyl) -1-cyclopropyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, a process for its preparation and its use as a medicament in ischaemic diseases which are associated with disorders of the microcirculation. This action can occur both in the peripheral and in the cerebral vascular system.

Specific 1,4-dihydropyridine-3,5-dicarboxylic acid ester, and its

Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl,

Haemorheological use of N-alkylated 1,4-dihydropyridine-dicarboxylic

The invention relates to the new dimethyl 2,6-dimethyl-1-n-propyl-4-(trifluoro-methylphenyl)-1,4-dihydropyridine-3-d icarboxylate, a process for its preparation and its use as a medicament in ischaemic diseases which are associated with disorders of the microcirculation. This action can occur both in the peripheral and in the cerebral vascular system.

Specific 1,4-dihydropyridine-3,5-dicarboxylic acid ester and its

N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters

2-Arylhydrazino-2-thiazolines, acyl derivatives of these compounds and 2-arylazo-2-thiazolines, of the general formula ##STR1## and salts thereof, are new, are prepared as described and find use for combating ectoparasites and endoparasites, such as cattle and sheep ticks, and gastric and intestinal nematodes in ruminants and carnivors.

2-Arylhydrazino-2-thiazolines, acyl derivatives of these compounds,

Acaricidal agents and compositions utilizing a 2-amino-.DELTA..sup.2 -thiazoline in which the amino group bears an ortho substituted phenyl group, naphth-l-yl, 5,6,7,8-tetrahydronaphth-l-yl or 1,3,5-trimethylpyrazol-4-yl, and salts thereof.

Substituted 2-amino-.DELTA..sup.2 -thiazoline derivatives as acaricidal

Oximes of the formula: ##SPC1## And their acid salts, wherein A is a branched or unbranched, saturated or unsaturated alkylene chain of 0-6 carbon atoms, B is a basic nitrogen-containing group such as an amino, alkylamino, dialkylamino, cycloalkylamino, dicycloalkylamino, cycloalkylalkylamino, dicycloalkylalkylamino, alkylarylamino, alkylaralkylamino, a piperidino, pyrrolidino, hexamethyleneimino, morpholino, thiomorpholino, N-alkylpiperazino or N-(2-hydroxyalkyl)-piperazino group, n is 1 or 2 and X is --CH.sub.2 --, --(CH.sub.2).sub.3 -- or --CH = CH--, and R.sub.1 and R.sub. 2 are each hydrogen, halogen, alkyl of 1-4 carbon atoms, alkoxy, alkylmercapto groups of 1-4 carbon atoms, hydroxyl, nitro, amino or trifluoromethyl, are useful for their anti-depressant activity. Pharmaceutical compositions may be prepared which comprise an anti-depressant amount of at least one such compound in combination with a pharmaceutically acceptable inert diluent or carrier. Depression in humans and animals may be treated by administering an anti-depressant amount of such an oxime to such human or animal.

Basic oximes and their preparation

1. A compound selected from the group consisting of And pharmaceutically acceptable non-toxic acid salts thereof.

Benzomorphanes of the formula: ##SPC1## Wherein

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Otto Behner