Dynamit Nobel Aktiengesellschaft

Otto Ackermann

Rudolf Stephan

Otto W Bleh, Deceased

Dieter Bretzinger

Herbert Schneidewind

Arnold Lenz

Gunther Meyer

Walter Rogler

Gerhard Daum

Hans Leuck

Gerhard Schmeling

Karl-Theo Von Meszoly

Dieter Morgenstern

An improvement in the alkoxylation of a compound having a reactive methylene group by contacting said compound with an orthoformic acid trialkyl ester in the presence of a catalyst, the improvement residing in employing at least 1.6 moles of orthoformic acid ester per mole of compound having a reactive methylene group and carrying out the process in the presence of a catalyst of the group of aliphatic carboxylic acids, anhydrides of aliphatic carboxylic acids, aromatic sulphonic acids, alkali metal alcoholates and alkanolamines.

Method of preparing alkoxymethylene compounds

A process for the preparation of substituted acetic acids and derivatives thereof, having the formula ##STR1## wherein X is --COOH, --COOY or --CN,

Process for the preparation of substituted acetic acids and derivatives

A process for the continuous production of an alkali metal alcoholate of a higher alcohol which comprises continuously introducing a higher alcohol into a reaction vessel, continuously introducing an alkali metal alcoholate of a lower alcohol into said reaction vessel and continuously and simultaneously distilling over and removing from said reaction vessel lower alcohol which forms.

Method for the continuous preparation of alcoholates

Process of producing a naphthyridine or quinoline compound of the formula: ##STR1## wherein R.sub.2, R.sub.3, R.sub.4, and R.sub.6 can be alkyl, and R.sub.1 is nitrogen or CH. The corresponding pyridyl- or phenylaminomethylenemalonic acid diester is cyclized to yield said compound and an alcohol. The malonic acid diester at below reaction temperature is added to a solvent, e.g., diphenyl benzene, at above reaction temperature in proportion so that the mixture attains reaction temperature. Good yields at high throughputs are achieved.

Process of performing cyclization reactions using benzyl or pyridylamino

Preparation of alkoxymethylene malonic acid ester of formula: ##STR1## wherein R and each R' is an alkyl group, by reaction of malonic acid diester and ortho formic acid triester. The reaction is performed in the presence of a carboxylic acid or a carboxylic acid anhydride and a Lewis acid. The ortho ester is initially present in amount of at least 1,4 mols per mole of the malonic acid ester starting material. Alcohol formed during the reaction is removed during the reaction.

Method of preparing alkoxymethylenemalonic acid esters

A process for preparing a pyridylaminomethylenemalonic acid derivative of the formula: ##STR1## which comprises reacting together a pyridyl compound of the formula: ##STR2## an alkoxy compound of the formula: ##STR3## and a malonic acid derivative of the formula selected of the group of ##STR4## wherein: R.sub.5 and R.sub.7 are the groups -- OOR.sub.4 or OOR.sub.5 or .tbd.N

Growing community of inventors

Troisdorf Sieglar, Germany

Otto Ackermann