Troponwerke Dinklage & Company

Otfried Brendler

Karl-Heinz Boltze

Peter-Rudolf Seidel

Haireddin Jacobi

Hans-Dieter Dell

Process for the production of a compound of the formula ##STR1## in which R stands for a benzyl radical or the radical ##STR2## and X is hydrogen or represents one or more substituents, wherein a compound of the formula ##STR3## is condensed with a compound of the formula ##STR4## in which R and X have the meaning indicated, at temperatures of at least 100.degree. C on an inert solvent as reaction medium, with formation of free HCl. The products are useful as intermediates for production of the corresponding indole derivatives wherein R is replaced by hydrogen or --CH.sub.2 COOH, which are antiphlogistically active compounds.

Process for the production of compounds with antiphlogistic activity

[1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-3-INDOLE]-ACETOXYACETIC ACID OF THE FORMULA ##SPC1## Possesses outstanding antiphlogistic activity without the side effects of certain conventional antiphlogistic pharmaceuticals.

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Cologne, Germany

Otfried Brendler