Richter Gedeon Vegyeszeti Gyar Rt

Oszkar Fuchs

Kalman Harsanyi

Gyorgy Fekete

Bela Hegedus

Lajos Toldy

Tibor Balogh

Jozsef Reiter

Endre Kasztreiner

Gyorgy Domany

Eva Againe Csongor

Tibor Lang

Janos Borvendeg

Margit Bidlo Nee Igloy

Ferenc Morasz

Arpad Lazar

Andras Rado

Tibor Somogyi

The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne monohydrate.

Cimetidine monohydrate

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Dunakesz, Hungary

Oszkar Fuchs