Bionebraska, Inc.

Avago Technologies General IP Pte, Ltd.

Osvaldo Lopez

Dwane E Wylie

Fred W Wagner

Peter Joseph Murray

Peter Goebel

Joel Morrison Lott

Metal binding polypeptides which include an amino acid sequence coding for a light chain variable region of a monoclonal antibody capable of immunoreacting with a lead cation and nucleotides which include a nucleic acid sequence coding for the variable region are provided. The invention is also directed to fusion proteins and Fab fragments which include the light chain variable region.

Lead binding polypeptides and nucleotides coding therefore

Metal binding polypeptides which include an amino acid sequence coding for a variable region of a monoclonal antibody which immunoreacts with a mercury cation and nucleotides which include a nucleic acid sequence coding for the variable region are provided. The invention is also directed to fusion proteins which include a phage coat protein or portion thereof and the monoclonal antibody heavy chain variable region. The invention also provides bacteriophages which include the fusion protein in their coat. In addition, methods for detecting, removing, adding, or neutralizing mercuric cations in biological or inanimate systems through the use of the mercury binding polypeptides are provided.

Mercury binding polypeptides and nucleotides coding therefore

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Lincoln, NE, United States of America

Osvaldo Lopez