Basf Aktiengesellschaft

Basf Se Corporation

Evonik Degussa Gmbh

Wintershall Holding Gmbh

Paik Kwang Industrial Co., Ltd.

Evolva Sa

Teagasc Dairy Products Research Centre

Basf Aktiencesellschaft

Oskar Zelder

Hartwig Schröder

Burkhard Kröger

Corinna Klopprogge

Markus Pompejus

Gregor Haberhauer

Stefan Haefner

Andrea Herold

Hartwig Schroder

Stefan Häfner

Christoph Wittmann

Joanna Martyna Krawczyk

Hartwig Schroeder

Birgit Hoff

Gregory Von Abendroth

Esther Dantas Costa

Klaus Ditrich

Michael Breuer

R Rogers Yocum

Stephan Freyer

Holger Hartmann

Weol Kyu Jeong

Hartwig Schr&ouml;der

Thomas A Patterson

Zheyuan Guo

Matthias Boy

Markus Lohscheidt

Mari Granström

Julia Kristiane Schmidt

Judith Becker

Wolfgang Siegel

Eckhard Stroefer

Karsten Koerber

Wolfgang Grabarse

Janice G Pero

Gerhard Schulz

Wolfgang Buckel

Michael Naesby

Martin Fiene

Bruno Kaesler

Markus Schwab

Christophe Folly

Catherine Stanton

Burkhard Ernst

Curt Aimé Friis Nielsen

Uwe Sauer

Andrea Molt

Mark K Williams

Elmar Heinzle

Christian Fleck

Corinna Kolpprogge

Heung-Shick Lee

Burkhard Kr&ouml;ger

Jakob Weber

Woncheol Kim

Jennifer Jaitzig

Stephan Saum

Beata Brockmann

René Stellmacher

Corrinna Klopprogge

Anaelle Hatsch

Nico Boehmer

Hyung-Joon Kim

Thomas J Lyons

Jun-Won Kim

Martin Völkert

Jens Kroemer

Theron Herman

Eudes De Crecy

Patrick Kiefer

Ewa Hughes

Uwe Ruffer

Claudia Isabella Graef

Heung Shick-Lee

Byung-Joon Hwang

R Paul Ross

Rüdiger Reingruber

Rüdiger Reingrubber

Christian Riedele

Torsten Renz

Ivana Djurdjevic

Jörg Mampel

Anna Lange

Anna Christine Schroer

Benjamin J Lyons

Anja Knietsch

Hartwig SCHRÖDER

Mari GRANSTRÖM

Mark Williams

Provided herein is a recombinant nucleic acid molecule, a recombinant microorganism, and a method for fermentative production of n-butylacrylate and other esters from alcohols and acyl-CoA units using alcohol acyl transferase enzymes.

Fermentative production of n-butylacrylate using alcohol acyl transferase enzymes

Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

Process for producing an organic compound

The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (Cin g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRin g per liter per hour).

Use of glycerol with limited feed of carbohydrates for fermentation

The present invention relates to a modified microorganism having, compared to its wildtype, &#x2014;a reduced activity of an enzyme encoded by the ptsA-gene, &#x2014;a reduced activity of an enzyme encoded by the ptsH-gene or &#x2014;a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.

Genetically modified microorganism for improved production of fine chemicals on sucrose

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.

Microorganisms for succinic acid production

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.

Modified microorganism with improved biomass separation behaviour

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.

Modified microorganism for improved production of fine chemicals on sucrose

Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Genes and processes for the production of clavine-type alkaloids

The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

Gene cluster for biosynthesis of cornexistin and hydroxycornexistin

The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity or the use of such a polypeptide for producing &#x3b2;-glucans. Furthermore, the present invention relates to methods for producing &#x3b2;-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity into a microorganism being able to synthesize &#x3b2;-glucans.

Genetically modified microorganisms capable of producing &#x3b2;-glucans and methods for producing &#x3b2;-glucans

Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans

The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising:

Fermentative production of fine chemicals

The invention relates to a method for isolating 1,5-diaminopentane (DAP) from DAP-containing fermentation broths, to a method for the fermentative production of DAP using said isolating method and to a method for producing DAP-comprising polymers by using the DAP isolated or fermatively produced DAPs according to said methods.

Method for fermentatively producing 1,5-diaminopentane

Growing community of inventors

Speyer, Germany

Oskar Zelder